Schizophrenia is a severe mental disorder affecting∼ 1% of the world population, with
heritability of up to 80%. To identify new common genetic risk factors, we performed a …

Schizophrenia is a severe psychiatric disorder with high heritability. Consortia efforts and
technological advancements have led to a substantial increase in knowledge of the genetic …

We examined the role of common genetic variation in schizophrenia in a genome-wide
association study of substantial size: a stage 1 discovery sample of 21,856 individuals of …

Importance Schizophrenia (SCZ) is a devastating psychiatric condition. Identifying the
specific genetic variants and pathways that increase susceptibility to SCZ is critical to …

Background Schizophrenia is a complex polygenic disorder with subtle, distributed
abnormalities in brain morphology. There are indications of shared genetic architecture …

Schizophrenia, a devastating psychiatric disorder, has a prevalence of 0.5–1%, with high
heritability (80–85%) and complex transmission. Recent studies implicate rare, large, high …

From our linkage study of Irish families with a high density of schizophrenia, we have
previously reported evidence for susceptibility genes in regions 5q21–31, 6p24–21, 8p22 …

Genetic architecture of a disease comprises the number, frequency, and effect sizes of
genetic risk alleles and the way in which they combine together. Before the genomic …

Background A recent analysis of 25 historical candidate gene polymorphisms for
schizophrenia in the largest genome-wide association study conducted to date suggested …

After two decades of frustration, genetic studies of schizophrenia have entered an era of
spectacular success. Advances in genotyping technologies and high throughput …