The emerging spectrum of allelic variation in schizophrenia: current evidence and strategies for the identification and functional characterization of common and rare …

BJ Mowry, J Gratten - Molecular psychiatry, 2013 - nature.com
After decades of halting progress, recent large genome-wide association studies (GWAS)
are finally shining light on the genetic architecture of schizophrenia. The picture emerging is …

Genetic modifiers and subtypes in schizophrenia: investigations of age at onset, severity, sex and family history

SE Bergen, CT O'Dushlaine, PH Lee, AH Fanous… - Schizophrenia …, 2014 - Elsevier
Schizophrenia is a genetically and clinically heterogeneous disorder. Genetic risk factors for
the disorder may differ between the sexes or between multiply affected families compared to …

Where GWAS and epidemiology meet: opportunities for the simultaneous study of genetic and environmental risk factors in schizophrenia

JJ McGrath, PB Mortensen, PM Visscher… - Schizophrenia …, 2013 - academic.oup.com
Epidemiologists and geneticists have tended to explore their respective domains
independently, and as a consequence, these fields have drifted apart. The aim of this article …

Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohort

L Athanasiu, M Mattingsdal, AK Kähler, A Brown… - Journal of psychiatric …, 2010 - Elsevier
We have performed a genome-wide association study (GWAS) of schizophrenia in a
Norwegian discovery sample of 201 cases and 305 controls (TOP study) with a focused …

Association between genetic variation in a region on chromosome 11 and schizophrenia in large samples from Europe

M Rietschel, M Mattheisen, F Degenhardt… - Molecular …, 2012 - nature.com
Recent molecular studies have implicated common alleles of small to moderate effect and
rare alleles with larger effect sizes in the genetic architecture of schizophrenia (SCZ). It is …

Biological insights from 108 schizophrenia-associated genetic loci

C Pantelis, GN Papadimitriou, S Papiol… - Nature, 2014 - nature.com
Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of
alleles, including common alleles of small effect that might be detected by genome-wide …

Genome scan of Arab Israeli families maps a schizophrenia susceptibility gene to chromosome 6q23 and supports a locus at chromosome 10q24

B Lerer, RH Segman, A Hamdan, K Kanyas… - Molecular …, 2003 - nature.com
Schizophrenia is a complex neuropsychiatric disorder to which an as-yet-unknown number
of genes contribute, interacting with each other and the environment. Linkage analyses have …

Genome‐Wide Findings in Schizophrenia and the Role of Gene–Environment Interplay

R Van Winkel, G Esquivel, G Kenis… - CNS neuroscience & …, 2010 - Wiley Online Library
The recent advent of genome‐wide mass‐marker technology has resulted in renewed
optimism to unravel the genetic architecture of psychotic disorders. Genome‐wide …

Genetic associations with schizophrenia: meta-analyses of 12 candidate genes

J Shi, ES Gershon, C Liu - Schizophrenia research, 2008 - Elsevier
Genetic association studies on schizophrenia (SZ) have been repeatedly performed over the
last two decades, resulting in a consensus that results are generally inconsistent. This …

Significant correlation in linkage signals from genome-wide scans of schizophrenia and schizotypy

AH Fanous, MC Neale, CO Gardner, BT Webb… - Molecular …, 2007 - nature.com
Prior family and adoption studies have suggested a genetic relationship between
schizophrenia and schizotypy. However, this has never been verified using linkage …