Importance Schizophrenia is a highly heritable, polygenic condition characterized by a
relatively diverse phenotype and frequent comorbid conditions, such as anxiety and …

Heritability analyses of genome-wide association study (GWAS) cohorts have yielded
important insights into complex disease architecture, and increasing sample sizes hold the …

Background There are high levels of comorbidity between schizophrenia and substance use
disorder, but little is known about the genetic etiology of this comorbidity. Methods We tested …

BACKGROUND:: Genome-wide association studies have detected a small number of weak
but strongly supported schizophrenia risk alleles. Moreover, a substantial polygenic …

In an effort to pinpoint potential genetic risk factors for schizophrenia, research groups
worldwide have published over 1,000 genetic association studies with largely inconsistent …

Schizophrenia is one of the most detrimental common psychiatric disorders, occurring at a
prevalence of approximately 1%, and characterized by increased mortality and reduced …

Abstract Background Polygenic risk scores (PRSs) have successfully summarized genome-
wide effects of genetic variants in schizophrenia with significant predictive power. In a …

BackgroundCandidate gene studies have been a key approach to the genetics of
schizophrenia (SCZ). However, the results of these studies are confusing and no genes …

Abstract The Schizophrenia Psychiatric Genome-Wide Association Study Consortium (PGC)
highlighted 81 single-nucleotide polymorphisms (SNPs) with moderate evidence for …

We report the clinical characteristics of a schizophrenia sample of 409 pedigrees—263 of
European ancestry (EA) and 146 of African American ancestry (AA)—together with the …