RGA Faragher, A McArdle, A Willows, EL Ostler - F1000Research, 2017 - ncbi.nlm.nih.gov
The accumulation of 'senescent'cells has long been proposed to act as an ageing mechanism. These cells display a radically altered transcriptome and degenerative …
DP de Carvalho, A Jacinto - Elife, 2021 - search.ebscohost.com
Cellular senescence is a highly complex and programmed cellular state with diverse and, at times, conflicting physiological and pathological roles across the lifespan of an organism …
Cellular senescence is a physiological mechanism whereby a proliferating cell undergoes a stable cell cycle arrest upon damage or stress and elicits a secretory phenotype. This highly …
LI Prieto, SI Graves, DJ Baker - Cells, 2020 - mdpi.com
Cellular senescence is the dynamic process of durable cell-cycle arrest. Senescent cells remain metabolically active and often acquire a distinctive bioactive secretory phenotype …
D Paramos-de-Carvalho, A Jacinto, L Saúde - Elife, 2021 - elifesciences.org
Cellular senescence is a highly complex and programmed cellular state with diverse and, at times, conflicting physiological and pathological roles across the lifespan of an organism …
Reliable ways to identify senescent cells represent a bottleneck for understanding the roles of senescence in physiology and disease. This Comment examines the challenges of …
E Prašnikar, J Borišek, A Perdih - Ageing Research Reviews, 2021 - Elsevier
As the world's population progressively ages, the burden on the socio-economic and health systems is escalating, demanding sustainable and lasting solutions. Cellular senescence …
U Tripathi, A Misra, T Tchkonia, JL Kirkland - Mechanisms of ageing and …, 2021 - Elsevier
Cellular senescence, first observed and defined through cell culture studies, is a cell fate associated with essentially permanent cell cycle arrest and that can be triggered by a variety …
The contribution of cellular senescence to a diverse range of biological processes, including normal physiology, ageing, and pathology were long overlooked but have now taken centre …