Accumulating evidence suggest that cerebral microvascular disease increases with
advancing age and is associated with lacunar stroke, leukoaraiosis, vascular dementia and …

Introduction Age‐related blood–brain barrier (BBB) disruption, cerebromicrovascular
senescence, and microvascular rarefaction substantially contribute to the pathogenesis of …

Alzheimer's disease (AD) is characterized by a progressive decline of cognitive functions
and represents the most common form of dementia and a major cause of morbidity and …

Vertebrates have acquired complex high-order functions facilitated by the dispersion of
vascular and neural networks to every corner of the body. Blood vessels deliver oxygen and …

Age-related and amyloid-induced pathology of the cerebral microvasculature have been
implicated as potential contributing factors to the pathogenesis of Alzheimer's disease (AD) …

The arteriosclerosis-dependent alteration of brain perfusion is one of the major determinants
in small vessel disease, since small vessels have a pivotal role in the brain's autoregulation …

Vascular insults can initiate a cascade of molecular events leading to neurodegeneration,
cognitive impairment, and dementia. Here, we review the cellular and molecular …

The cerebral vascular system stringently regulates cerebral blood flow (CBF). The
components of the blood–brain barrier (BBB) protect the brain from pathogenic infections …

There is growing evidence suggesting that vascular pathologies and dysfunction play a
critical role in cognitive impairment, clinical Alzheimer's disease, and dementia. Vascular …

Background Functional loss of blood–brain barrier (BBB) is suggested to be pivotal to
pathogenesis and pathology of vascular-based neurodegenerative disorders such as …