Tailoring multi-omics to inflammatory bowel diseases: all for one and one for all

P Sudhakar, D Alsoud, J Wellens… - Journal of Crohn's …, 2022 - academic.oup.com
Inflammatory bowel disease [IBD] has a multifactorial origin and originates from a complex
interplay of environmental factors with the innate immune system at the intestinal epithelial …

Multi-omics analysis of inflammatory bowel disease

H Huang, P Vangay, CE McKinlay, D Knights - Immunology letters, 2014 - Elsevier
Crohn's disease and ulcerative colitis, known together as inflammatory bowel disease (IBD),
are severe autoimmune disorders now causing gut inflammation and ulceration, among …

Multiomics to elucidate inflammatory bowel disease risk factors and pathways

M Agrawal, KH Allin, F Petralia, JF Colombel… - Nature Reviews …, 2022 - nature.com
Inflammatory bowel disease (IBD) is an immune-mediated disease of the intestinal tract, with
complex pathophysiology involving genetic, environmental, microbiome, immunological and …

Inflammatory bowel disease meets systems biology: a multi-omics challenge and frontier

O Palmieri, T Mazza, S Castellana, A Panza… - OMICS: A Journal of …, 2016 - liebertpub.com
The inflammatory bowel disease (IBD) is a systemic disease that is characterized by the
inflammation of the gastrointestinal tract. It includes ulcerative colitis and the Crohn's …

The 1000IBD project: multi-omics data of 1000 inflammatory bowel disease patients; data release 1

F Imhann, KJ Van der Velde, R Barbieri, R Alberts… - BMC …, 2019 - Springer
Background Inflammatory bowel disease (IBD) is a chronic complex disease of the
gastrointestinal tract. Patients with IBD can experience a wide range of symptoms, but the …

Recent advances in the etiopathogenesis of inflammatory bowel disease: the role of omics

E Stylianou - Molecular diagnosis & therapy, 2018 - Springer
Omics technology presents an exciting and timely opportunity to improve our understanding
of the molecular etiology and pathogenesis of the group of chronic, heterogeneous …

Genetics and environmental interactions shape the intestinal microbiome to promote inflammatory bowel disease versus mucosal homeostasis

RB Sartor - Gastroenterology, 2010 - gastrojournal.org
Recent genome-wide genetic association studies and advances in molecular analysis of
microbial composition have improved dramatically our understanding of the pathogenesis of …

Inflammatory bowel disease pathogenesis: where are we?

C Fiocchi - Journal of gastroenterology and hepatology, 2015 - Wiley Online Library
Inflammatory bowel disease (IBD) is presently one of the most investigated human
disorders. Expansion of knowledge of its pathophysiology has helped in developing novel …

Clinical value of multi-omics-based biomarker signatures in inflammatory bowel diseases: challenges and opportunities

AR Bourgonje, H van Goor, KN Faber… - Clinical and …, 2022 - journals.lww.com
Inflammatory bowel diseases (IBD), encompassing Crohn's disease (CD) and ulcerative
colitis (UC), are complex and heterogeneous diseases characterized by a multifactorial …

Poly-omic risk scores predict inflammatory bowel disease diagnosis

CH Arehart, JD Sterrett, RL Garris, RE Quispe-Pilco… - Msystems, 2024 - Am Soc Microbiol
Inflammatory bowel disease (IBD) is characterized by complex etiology and a disrupted
colonic ecosystem. We provide a framework for the analysis of multi-omic data, which we …