[HTML][HTML] Alveolar macrophage dysfunction and cytokine storm in the pathogenesis of two severe COVID-19 patients

C Wang, J Xie, L Zhao, X Fei, H Zhang, Y Tan, X Nie… - …, 2020 - thelancet.com
Background The novel coronavirus pneumonia COVID-19 caused by SARS-CoV-2 infection
could lead to a series of clinical symptoms and severe illnesses, including acute respiratory …

[HTML][HTML] Role of senescence in the chronic health consequences of COVID-19

EOW Gerdes, G Vanichkachorn, BP Verdoorn… - Translational …, 2022 - Elsevier
While the full impact of COVID-19 is not yet clear, early studies have indicated that upwards
of 10% of patients experience COVID-19 symptoms longer than 3 weeks, known as Long …

[HTML][HTML] COVID-19: towards understanding of pathogenesis

W Cao, T Li - Cell research, 2020 - nature.com
The pandemic of coronavirus disease 2019 (COVID-19) is spreading rapidly. Although the
cause was quickly identified as a new coronavirus named SARS-CoV-2, our knowledge of …

[HTML][HTML] Aging, immunity, and COVID-19: how age influences the host immune response to coronavirus infections?

V Bajaj, N Gadi, AP Spihlman, SC Wu, CH Choi… - Frontiers in …, 2021 - frontiersin.org
The novel coronavirus severe acute respiratory syndrome coronavirus 2 causing the
Coronavirus disease (COVID-19) pandemic has ravaged the world with over 72 million total …

Inflammaging at the Time of COVID-19

MB Zazzara, A Bellieni, R Calvani… - Clinics in Geriatric …, 2022 - geriatric.theclinics.com
Inflammaging and SARS-CoV-2 infection interact in an interplay that involves both acute
inflammation and low-grade chronic inflammation, predisposing older adults to severe …

[HTML][HTML] Age-induced NLRP3 inflammasome over-activation increases lethality of SARS-CoV-2 pneumonia in elderly patients

PC Lara, D Macías-Verde, J Burgos-Burgos - Aging and disease, 2020 - ncbi.nlm.nih.gov
Age is one of the most important prognostic factors associated to lethality in SARS-CoV-2
infection. In multivariate analysis, advanced age was an independent risk factor for death …

[HTML][HTML] Cytokine profiles associated with acute COVID-19 and long COVID-19 syndrome

MAF Queiroz, PFM Neves, SS Lima… - Frontiers in cellular …, 2022 - frontiersin.org
The duration and severity of COVID-19 are related to age, comorbidities, and cytokine
synthesis. This study evaluated the impact of these factors on patients with clinical …

Emerging aspects of cytokine storm in COVID-19: The role of proinflammatory cytokines and therapeutic prospects

R Dharra, AK Sharma, S Datta - Cytokine, 2023 - Elsevier
COVID-19 has claimed millions of lives during the last 3 years since initial cases were
reported in Wuhan, China, in 2019. Patients with COVID-19 suffer from severe pneumonia …

[HTML][HTML] Long COVID: A proposed hypothesis-driven model of viral persistence for the pathophysiology of the syndrome

D Buonsenso, M Piazza, AL Boner… - Allergy and Asthma …, 2022 - ncbi.nlm.nih.gov
Background: Long COVID (coronavirus disease 2019) syndrome includes a group of
patients who, after infection with severe acute respiratory syndrome coronavirus 2 (SARS …

COVID-19 pathophysiology: A review

K Yuki, M Fujiogi, S Koutsogiannaki - Clinical immunology, 2020 - Elsevier
In December 2019, a novel coronavirus, now named as SARS-CoV-2, caused a series of
acute atypical respiratory diseases in Wuhan, Hubei Province, China. The disease caused …