LIPOSOMES AS A LIPID-BASED FORMULATION TO INCREASE THE BIOAVAILABILITY OF POORLY WATER-SOLUBLE DRUG FENOFIBRATE

A Nemati - 2019 - archiv.ub.uni-heidelberg.de
This thesis investigates the biopharmaceutical knowledge of different liposomal formulations
using two different phosphatidylcholines (EPC and S 90) in the presence and absence of …

Enhanced bioavailability of the poorly water-soluble drug fenofibrate by using liposomes containing a bile salt

Y Chen, Y Lu, J Chen, J Lai, J Sun, F Hu… - International journal of …, 2009 - Elsevier
The main purpose of this study was to evaluate oral bioavailability of the poorly water-
soluble drug fenofibrate when liposomes containing a bile salt were used as oral drug …

Formulation and evaluation of liposomes of fenofibrate prepared by thin film hydration technique

SG Amin - 2017 - search.proquest.com
Despite the enormous amount of effort spent during the past 44 years (greater than 114,000
scientific publications) and the well-formed consensus within the scientific community about …

The conflict between in vitro release studies in human biorelevant media and the in vivo exposure in rats of the lipophilic compound fenofibrate

TT Do, M Van Speybroeck, R Mols, P Annaert… - International journal of …, 2011 - Elsevier
The performance of four different lipid-based (Tween 80–Captex 200P, Tween 80–Capmul
MCM, Tween 80–Caprol 3GO and Tween 80–soybean oil) and one commercially available …

Liposome formulation of poorly water soluble drugs: optimisation of drug loading and ESEM analysis of stability

AR Mohammed, N Weston, AGA Coombes… - International journal of …, 2004 - Elsevier
Liposomes due to their biphasic characteristic and diversity in design, composition and
construction, offer a dynamic and adaptable technology for enhancing drug solubility …

Investigating the correlation between in vivo absorption and in vitro release of fenofibrate from lipid matrix particles in biorelevant medium

N Borkar, D Xia, R Holm, Y Gan, A Müllertz… - European Journal of …, 2014 - Elsevier
Lipid matrix particles (LMP) may be used as better carriers for poorly water-soluble drugs
than liquid lipid carriers because of reduced drug mobilization in the formulations. However …

[PDF][PDF] Design and evaluation of flurbiprofen liposomes

MY Begum, K Abbulu, M Sudhakar - J Pharm Res, 2011 - Citeseer
The aim of this study was to examine the encapsulation of flurbiprofen in to liposomes and
further to achieve sustained as well as controlled release pattern of flurbiprofen from multi …

In Vitro Lipolysis Data Does Not Adequately Predict the In Vivo Performance of Lipid-Based Drug Delivery Systems Containing Fenofibrate

N Thomas, K Richter, TB Pedersen, R Holm, A Müllertz… - The AAPS journal, 2014 - Springer
The present study investigated the utility of in vitro lipolysis performance indicators drug
solubilization and maximum supersaturation ratio (SR M) for their predictive use for the in …

In vitro assessment of drug-free and fenofibrate-containing lipid formulations using dispersion and digestion testing gives detailed insights into the likely fate of …

R Devraj, HD Williams, DB Warren, K Mohsin… - European Journal of …, 2013 - Elsevier
The solubilizing properties of lipid-based formulations (LBFs) can change dramatically
following dispersion and digestion of the formulation components. This study investigated …

Using in vitro lipolysis and SPECT/CT in vivo imaging to understand oral absorption of fenofibrate from lipid-based drug delivery systems

T Tran, P Bønløkke, C Rodríguez-Rodríguez… - Journal of Controlled …, 2020 - Elsevier
Using lipid-based drug delivery systems (LbDDS) is an efficient strategy to enhance the low
oral bioavailability of poorly water-soluble drugs. Here the oral absorption of fenofibrate (FF) …