Age at menarche (AAM) is a sign of puberty of females. It is a heritable trait associated with
various adult diseases. However, the genetic mechanism that determines AAM and links it to …

African-American (AA) women have earlier menarche on average than women of European
ancestry (EA), and earlier menarche is a risk factor for obesity and type 2 diabetes among …

Early menarche is associated with adverse health outcomes, including breast cancer,
endometrial cancer, obesity, type 2 diabetes, and cardiovascular disease. Recently, a …

Objective An early onset of menarche and, later, menopause are well-established risk
factors for the development of breast cancer and endometrial cancer. Although the largest …

Age at menarche (AAM) is a complex trait involving both genetic and environmental factors.
To identify the genetic factors associated with AAM, we conducted a large-scale meta …

Context: Age at menarche (AAM) is an important anthropological variable that has major
implications for a woman's health later in life. Genetic influence has been shown to …

Age at menarche (AM) and age at natural menopause (ANM) are complex traits with a high
heritability. Abnormal timing of menarche or menopause is associated with a reduced span …

STUDY QUESTION Are there associations of age at menarche (AAM) with health-related
outcomes in East Asians? SUMMARY ANSWER AAM is associated with osteoporosis, Type …

To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide
association studies in 87,802 women of European descent, with replication in up to 14,731 …

Younger age at menarche (AAM) is associated with higher body mass index (BMI) for young
women. Considering that continuous trends in decreasing AAM and increasing BMI are …