Background: Testosterone treatment rates in adult men have increased in the United States
over the past 2 decades. Purpose: To assess the benefits and harms of testosterone …

Description: The American College of Physicians (ACP) developed this guideline to provide
clinical recommendations based on the current evidence of the benefits and harms of …

Cunningham and Toma have published an article enti-tled “Why Is Androgen Replacement
in Males Controversial?”(1) in this issue of JCEM. This represents a new look at an old …

Testosterone products are approved by the US Food and Drug Administration (FDA) as
replacement therapy for men with classical androgen deficiency (ie men with very low serum …

Context: The risks of testosterone therapy in men remain poorly understood. Objective: The
aim of this study was to conduct a systematic review and meta-analyses of testosterone trials …

Background Serum testosterone concentrations decrease as men age, but benefits of
raising testosterone levels in older men have not been established. Methods We assigned …

Testosterone therapy is increasingly common in the United States, and many of these
prescriptions are written by primary care physicians. There is conflicting evidence on the …

The substantial increase in life expectancy of men has focused growing attention on quality-
of-life issues associated with reproductive aging. Serum total and free testosterone levels in …

Testosterone therapy (TTh) has become highly controversial. There are important health
consequences of testosterone deficiency, and meaningful benefits with treatment. There is …

Aging is variably but inevitably accompanied by declines in health; concomitantly, in men,
circulating sex-steroid levels fall with age. 1 To what extent these two processes are causally …