Blood–brain barrier dysfunction in status epileptics: Mechanisms and role in epileptogenesis

E Swissa, Y Serlin, U Vazana, O Prager, A Friedman - Epilepsy & Behavior, 2019 - Elsevier
… epilepticus, and in epileptogenic brain regions, may last for months. Blood–brain barrier
dysfunction was shown to have a role in astroglial dysfunction, neuroinflammation, increasing …

Structural, molecular, and functional alterations of the blood-brain barrier during epileptogenesis and epilepsy: a cause, consequence, or both?

W Löscher, A Friedman - International journal of molecular sciences, 2020 - mdpi.com
… The blood–brain barrier (BBB) is a dynamic and complex barrier essential for the normal
function of the central nervous system (CNS). The existence of a physical interface between the …

Imaging blood–brain barrier dysfunction as a biomarker for epileptogenesis

G Bar-Klein, S Lublinsky, L Kamintsky, I Noyman… - Brain, 2017 - academic.oup.com
… blood–brain barrier dysfunction and neuroinflammation. … anti-epileptogenic interventions
were used; isoflurane anaesthesia and losartan. Our results show that early blood–brain barrier

Krüppel-like factors: potential roles in blood-brain barrier dysfunction and epileptogenesis

AB Santos, A Carona, M Ettcheto, A Camins… - Acta Pharmacologica …, 2024 - nature.com
… vascular function and … roles in cerebrovascular dysfunction and epileptogenesis. This review
critically discusses the purpose of KLFs in epileptogenic mechanisms and BBB dysfunction, …

The role of inflammation in epileptogenesis

F Meng, L Yao - Acta Epileptologica, 2020 - Springer
… excitation as well as blood-brain barrier (BBB) dysfunction, and finally trigger the … roles of
inflammatory mediators, including inflammatory cytokines, cells, and BBB, in epileptogenesis

Breaking bad: the structure and function of the blood-brain barrier in epilepsy

H Han, A Mann, D Ekstein, S Eyal - The AAPS journal, 2017 - Springer
… , similarly to studies of other brain disorders. An additional source … aimed at resecting the
epileptogenic brain tissue. Since … on the hippocampus, a main epileptogenic structure within the …

Activation of the innate immune system is evident throughout epileptogenesis and is associated with blood‐brain barrier dysfunction and seizure progression

DWM Broekaart, JJ Anink, JC Baayen, S Idema… - …, 2018 - Wiley Online Library
… epilepsy models show that brain inflammation can enhance … epileptogenesis could help
to determine the role of inflammation in the progression of epilepsy and is of crucial importance

Evidence for peri-ictal blood–brain barrier dysfunction in patients with epilepsy

T Rüber, B David, G Lüchters, RD Nass, A Friedman… - Brain, 2018 - academic.oup.com
… contributes to epileptogenesis, blood–brain barrier dysfunction … We hypothesized that
blood–brain barrier dysfunction is temporally … role in the mediation of peri-ictal blood–brain barrier

The roof is leaking and a storm is raging: repairing the blood–brain barrier in the fight against epilepsy

JA Gorter, E Aronica, EA Van Vliet - Epilepsy currents, 2019 - journals.sagepub.com
… Research into the role of the blood–brain barrier (BBB) in epilepsy … epileptogenic brain
tissue. At the same time it has become increasingly clear that (neuro)inflammation may play a role

Multimodality imaging of blood–brain barrier impairment during epileptogenesis

H Breuer, M Meier, S Schneefeld… - Journal of Cerebral …, 2017 - journals.sagepub.com
… Our findings will help to further evaluate the role of BBB impairment in epileptogenesis
and provide a potential method to optimize timing of BBB protective treatment approaches. …