[HTML][HTML] SARS-CoV-2 vaccines in development

F Krammer - Nature, 2020 - nature.com
coronavirus 2 (SARS-CoV-2) was first reported in late 2019 in China and is the causative
agent of the coronavirus … Here I review the development of vaccines against SARS-CoV-2. …

Low-dose Ad26. COV2. S protection against SARS-CoV-2 challenge in rhesus macaques

X He, A Chandrashekar, R Zahn, F Wegmann, J Yu… - Cell, 2021 - cell.com
… single immunization with relatively low dose of Ad26.… doses in protecting different anatomic
respiratory compartments, and assess the possibility of VAERD. We observed that low doses

… of high vs low doses of chloroquine diphosphate as adjunctive therapy for patients hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

MGS Borba, FFA Val, VS Sampaio… - JAMA network …, 2020 - jamanetwork.com
Importance There is no specific antiviral therapy recommended for coronavirus disease 2019
(COVID-19). In vitro studies indicate that the antiviral effect of chloroquine diphosphate (CQ…

Low-dose in vivo protection and neutralization across SARS-CoV-2 variants by monoclonal antibody combinations

V Dussupt, RS Sankhala, L Mendez-Rivera… - Nature …, 2021 - nature.com
… of pseudotyped SARS-CoV-2 … by SARS-CoV-2 infection by using peripheral blood mononuclear
cells (PBMCs) from Donor 3 in two independent sorting strategies to isolate SARS-CoV-2…

Dose-dependent response to infection with SARS-CoV-2 in the ferret model and evidence of protective immunity

KA Ryan, KR Bewley, SA Fotheringham… - Nature …, 2021 - nature.com
… A low dose intranasal challenge of the same SARS-CoV-2 virus (5 × 10 2 pfu) appeared to
result in infection of only one ferret which shed detectable viral RNA in the upper respiratory …

SARS-CoV-2 vaccines

CB Creech, SC Walker, RJ Samuels - Jama, 2021 - jamanetwork.com
… sufficient quantities of vaccine, could we imagine giving a lower dose ie 20-25 ug of the Pfizer-…
ug dosing), sparing at least one additional dose per vial, especially with people with lower

Low dose inocula of SARS-CoV-2 Alpha variant transmits more efficiently than earlier variants in hamsters

BWY Mok, H Liu, S Deng, J Liu, AJ Zhang… - Communications …, 2021 - nature.com
… using a lower infectious dose, we … SARS-CoV-2 transmission dynamics is important for
designing appropriate strategies for a more effective response to emerging variants of SARS-CoV

Hamster and ferret experimental infection with intranasal low dose of a single strain of SARS-CoV-2

E Monchatre-Leroy, S Lesellier… - Journal of General …, 2021 - microbiologyresearch.org
… Understanding the pathogenesis of the SARS-CoV-2 infection is key to developing …
SARS-CoV-2 intranasal infection in ferrets and hamsters with low doses of low-passage SARS-CoV-…

[HTML][HTML] Low-dose and oral exposure to SARS-CoV-2 may help us understand and prevent severe COVID-19

WP Hausdorff, J Flores - International Journal of Infectious Diseases, 2021 - Elsevier
Background The effectiveness and sustainability of current public health interventions designed
to prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission …

Development of an inactivated vaccine candidate for SARS-CoV-2

Q Gao, L Bao, H Mao, L Wang, K Xu, M Yang, Y Li… - Science, 2020 - science.org
… two vaccine doses and then inoculated with SARS-CoV-2. Those that received the lowest
dose showed signs of controlling the infection, and those receiving the highest dose appeared …