Randomized trial of molnupiravir or placebo in patients hospitalized with Covid-19

JR Arribas, S Bhagani, SM Lobo, I Khaertynova… - NEJM …, 2022 - evidence.nejm.org
virus lead to viral extinction. In an animal model, molnupiravir retained full efficacy against
SARS-CoV-2 variants of concern. The favorable safety and tolerability profile of molnupiravir

Molnupiravir and nirmatrelvir/ritonavir: tolerability, safety, and adherence in a retrospective cohort study

M Mazzitelli, D Mengato, L Sasset, A Ferrari, S Gardin… - Viruses, 2023 - mdpi.com
… were randomized to receive molnupiravir or placebo for 5 days, within 5 days from SARS-CoV-2
symptom’s onset [5]. Results from this study confirmed that molnupiravir, compared to …

Efficacy and safety of molnupiravir in adult outpatients with COVID-19

NY Pshenichnaya, KG Omarova… - Almanac of Clinical …, 2023 - almclinmed.ru
SARS-CoV-2 на предыдущем визите осуществлялся выезд медицинского персонала
для … мазка из носоглотки и/или ротоглотки для проведения анализа РНК SARS-CoV-2. …

Molnupiravir for treatment of adults with mild or moderate COVID-19: a systematic review and meta-analysis of randomized controlled trials

Y Gao, M Liu, Z Li, J Xu, J Zhang, J Tian - Clinical Microbiology and …, 2023 - Elsevier
… , an oral antiviral drug, has been shown to induce SARS-CoV-2 RNA … safety of molnupiravir
in treating patients with mild-to-moderate COVID-19. Our findings reveal that molnupiravir

Molnupiravir for oral treatment of Covid-19 in nonhospitalized patients

A Jayk Bernal, MM Gomes da Silva… - … England Journal of …, 2022 - Mass Medical Soc
… Here we report efficacy and safety results from the phase … molnupiravir over SARS-CoV-2
spike protein–directed monoclonal antibodies is the efficacy of molnupiravir against SARS-CoV

Virology and safety profile of Molnupiravir at three different doses for treatment of SARS‐C o V‐2: a systematic review and meta‐analysis

M Sukaina, SH Shuja, ST Rehan, S Ochani, M Sheryar - APMIS, 2024 - Wiley Online Library
… In our meta-analysis, we conclude that Molnupiravir has a significant effect in treating
SARS-CoV-2 patients. The results demonstrate the efficacy of Molnupiravir in the hierarchy of …

Molnupiravir promotes SARS-CoV-2 mutagenesis via the RNA template

CJ Gordon, EP Tchesnokov, RF Schinazi… - Journal of Biological …, 2021 - ASBMB
… a mechanism of action of molnupiravir that is primarily based … However, the biochemical
mechanisms involved in molnupiravir-… molnupiravir drives SARS-CoV-2 into error catastrophe. …

Molnupiravir: first approval

YY Syed - Drugs, 2022 - Springer
Molnupiravir inhibited SARS-CoV-2 in human airway epithelial cell cultures; in SARS-CoV-2-infected
mice, molnupiravir … , virologic and safety outcomes across the molnupiravir clinical …

Rapid review and meta‐analysis of adverse events associated with molnupiravir in patients with COVID‐19

B Amani, S Zareei, B Amani - British Journal of Clinical …, 2022 - Wiley Online Library
… the safety profile of molnupiravir in COVID-19 patients. … terms were SARS-CoV-2, COVID-19,
molnupiravir and adverse … ((((((Coronavirus[Title/Abstract]) OR (Coronavirus[MeSH Terms])) …

Efficacy and safety of nirmatrelvir/ritonavir, molnupiravir, and remdesivir in a real-world cohort of outpatients with COVID-19 at high risk of progression: the PISA …

G Tiseo, C Barbieri, V Galfo, S Occhineri… - Infectious Diseases and …, 2023 - Springer
… frequent in patients treated with remdesivir (5.1%) compared with molnupiravir (1.8%) or
nirmatrelvir/ritonavir (0.8%, … Safety and time to a negative test differed among the three drugs. …