Molnupiravir versus placebo in unvaccinated and vaccinated patients with early SARS-CoV-2 infection in the UK (AGILE CST-2): a randomised, placebo-controlled …

SH Khoo, R FitzGerald, G Saunders… - The Lancet Infectious …, 2023 - thelancet.com
… We aimed to evaluate the safety and virological efficacy of molnupiravir in vaccinated and …
molnupiravir for adults with documented SARS-CoV-2 infection: 800 mg every 12 h for 5 days. …

What impact can molnupiravir have on the treatment of SARS-CoV-2 infection?

F Kayali, MST Leung, W Wong… - Expert Opinion on …, 2022 - Taylor & Francis
… (RNA) virus has caused more … SARS-CoV-2 variants and protection of immunosuppressed
patients [7]. This stresses the urgency of investigating and implementing efficient and safe

Safety Profile of Molnupiravir with Significant Effect on COVID-19: A Review

T Mukherjee, P Mal, AK Upadhyay… - Current Drug …, 2023 - ingentaconnect.com
… been immunised against SARSCoV-2 and had SARS-CoV-2 infection and symptoms within
5 days of enrollment. Subjects were randomly allocated to receive 800 mg of molnupiravir or …

Real-world effectiveness of molnupiravir and nirmatrelvir plus ritonavir against mortality, hospitalisation, and in-hospital outcomes among community-dwelling …

CKH Wong, ICH Au, KTK Lau, EHY Lau, BJ Cowling… - The Lancet, 2022 - thelancet.com
Background Little is known about the real-world effectiveness of oral antivirals against the
SARS-CoV-2 omicron (B.1.1.529) variant. We aimed to assess the clinical effectiveness of two …

[HTML][HTML] The pill of recovery; Molnupiravir for treatment of COVID-19 patients; a systematic review

L Kamal, A Ramadan, S Farraj, L Bahig… - Saudi Pharmaceutical …, 2022 - Elsevier
… Here, a systematic review on the cumulative evidence of molnupiravir safety and anti-viral
activity is … Negativity of SARS CoV-2 RT-PCR was early observed in Molnupiravir group in …

Accelerated first-in-human clinical trial of EIDD-2801/MK-4482 (molnupiravir), a ribonucleoside analog with potent antiviral activity against SARS-CoV-2

W Holman, W Holman, S McIntosh, W Painter… - Trials, 2021 - Springer
… The initial SAD cohort included dosing of two sentinel subjects, each one assigned to either
molnupiravir or placebo. The safety results for the sentinel group were reviewed 24 h post-…

The combined treatment of Molnupiravir and Favipiravir results in a potentiation of antiviral efficacy in a SARS-CoV-2 hamster infection model

R Abdelnabi, CS Foo, SJF Kaptein, X Zhang… - …, 2021 - thelancet.com
… effect of the combination of Molnupiravir and Favipiravir in the SARS-CoV-2 hamster infection
… who received molnupiravir (0/47) as compared to placebo (6/25). No safety signals were …

Could chlorophyllins improve the safety profile of beta-d-N4-hydroxycytidine versus N-hydroxycytidine, the active ingredient of the SARS-CoV-2 antiviral molnupiravir?

NF Clark, AW Taylor-Robinson… - … in Drug Safety, 2022 - journals.sagepub.com
Molnupiravir, a specific SARS-CoV-2 … of molnupiravir, typically used to treat patients suffering
from COVID-19. Chlorophyllins, antioxidants derived from natural plant chlorophyll, are safe

A molnupiravir-associated mutational signature in global SARS-CoV-2 genomes

T Sanderson, R Hisner, I Donovan-Banfield, H Hartman… - Nature, 2023 - nature.com
… -derived lineages, will be an important consideration for assessing the effects and
evolutionary safety of this drug. Our results are consistent with recent observations in …

A systematic review of the global intervention for SARS-CoV-2 combating: from drugs repurposing to molnupiravir approval

NA Ashour, A Abo Elmaaty, AA Sarhan… - Drug design …, 2023 - Taylor & Francis
SARS-CoV-2 continues to unfold all over the world. The development of novel effective antiviral
drugs to fight against SARS-CoV… Recently, molnupiravir is a prodrug antiviral medication …