… Gene silencing by RNAi was first observed in 1998 by Craig Mello … of therapeutic miRNAs
and siRNAs. We present insights regarding significant siRNAs and miRNAs in the therapeutic …

… miRNA regulation or enhanced gene silencing by miRNA may affect the efficacy of miRNA
therapeutics… the context-dependent nature of miRNA regulatory function. Indeed, wide-spread …

… Meanwhile, microRNAs (miRNAs) have also been exploited for the treatment of liver
fibrosis. This review focuses on the current siRNA- and miRNA-based liver fibrosis treatment …

… understanding will also provide new therapeutic targets and candidates for gene silencing.
In order to appreciate the potential therapeutic application of gene silencing, it is important to …

… miRNA drugs (another therapeutic similar to siRNA drug). Here we report the existing obstacles
of miRNA therapeutics … exactly endow siRNA giving them the purpose of gene silencing, …

… For example, the natural mechanism of gene expression regulation by RNA interference (RNAi)
[6], discovered during the 1990s, has fewer biological barriers to gene silencing than …

… that target miRNAs. Here, we present an overview of investigations into miRNAs and their
impact on gene expression. Progress in our understanding of miRNAs would be aided by a …

… RNA interference (RNAi) approach, siRNA is a powerful tool for modulating gene expression
through gene silencing. … in the clinical application of siRNA, including unfavorable immune …

… In cultured cells and mice, the constructs effectively mediated gene silencing at a level
similar to the corresponding shRNA. Furthermore, miR-33-based amiRNAs were accurately …

… siRNA and miRNA, siRNA can typically trigger more efficient and specific gene silencing than
miRNA, whereas one miRNA may … of several different target genes simultaneously. Hence, …