CD4+ T-Cell Dysfunction in Severe COVID-19 Disease Is Tumor Necrosis Factor-α/Tumor Necrosis Factor Receptor 1–Dependent

I Popescu, ME Snyder, CJ Iasella… - American journal of …, 2022 - atsjournals.org
… role for inflammatory mediators or “cytokine storm” in the course of disease, as multiple
studies have shown increased systemic levels of cytokines during moderate and severe COVID-…

The cytokine storm in COVID-19: the strongest link to morbidity and mortality in the current epidemic

M Basheer, E Saad, N Assy - COVID, 2022 - mdpi.com
… Patients treated with anti-tumor necrosis factor, vedolizumab, or ustekinumab (IBD
treatments) are typical for COVID-19, and the incidence and mortality is similar to that in the …

Detection of early cytokine storm in patients with septic shock after abdominal surgery

J Chao, S Cui, C Liu, S Liu, S Liu, Y Han… - Journal of …, 2020 - degruyter.com
cytokines: tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-8, IL-10, monocyte chemotactic
protein (MCP)-1, IL-1 β, interferon-γ, IL-12p70, MCP-1α, IL-4, IL-2, and IL-13. Experiments …

Cytokine storm induced by SARS-CoV-2 infection: The spectrum of its neurological manifestations

P Thepmankorn, J Bach, A Lasfar, X Zhao, S Souayah… - Cytokine, 2021 - Elsevier
cytokine levels known as hypercytokinemia or cytokine storm, observed most often in
severe patients. Though COVID-19 is known to be a primarily respiratory disease, neurological …

How COVID-19 induces cytokine storm with high mortality

S Hojyo, M Uchida, K Tanaka, R Hasebe… - Inflammation and …, 2020 - Springer
… , tumor necrosis factor (TNF), granulocyte colony-stimulating … that IL-6 inhibitors including
TCZ could mitigate cytokine storms … that found IL-6 inhibitors could suppress cytokine storms in …

Cytokine storm syndrome

RQ Cron, G Goyal, WW Chatham - Annual Review of Medicine, 2023 - annualreviews.org
… Elevated levels of IL-6, tumor necrosis factor (TNF), MCP-1, granulocyte colony-stimulating
factor (G-CSF), macrophage inflammatory protein 1α (MIP-1α), and soluble IL-2 receptor α (…

[HTML][HTML] Cytokine storm in novel coronavirus disease (COVID-19): expert management considerations

Y Mehta, SB Dixit, KG Zirpe… - Indian journal of critical …, 2020 - ncbi.nlm.nih.gov
… interleukin (IL)-2, IL-6, IL-7, granulocyte colony-stimulating factor (GCS-F), interferon-γ (INF-γ…
), macrophage inflammatory protein 1-α (MIP 1-α), and tumor necrosis factor-α (TNF-α). This …

TNFα inhibitor may be effective for severe COVID-19: learning from toxic epidermal necrolysis

XY Chen, BX Yan, XY Man - Therapeutic Advances in …, 2020 - journals.sagepub.com
… inflammatory cytokines [such as tumor necrosis factor alpha (TNFα) and interleukin-6 (IL-6)] …
The process of cytokine storm could mediate the apoptosis of epithelial cells in lung and skin…

Targeting tumour necrosis factor to ameliorate viral pneumonia

P Pandey, G Karupiah - The FEBS journal, 2022 - Wiley Online Library
… by excessive inflammation associated with dysregulated cytokine production, termed ‘cytokine
storm’. Several cytokines have been implicated but tumour necrosis factor (TNF) plays a …

Point‐of‐care detection of cytokines in cytokine storm management and beyond: Significance and challenges

G Liu, C Jiang, X Lin, Y Yang - View, 2021 - Wiley Online Library
… significance of cytokines. [ 3 ] The early recognition of cytokine storm by monitoring cytokine
levels … product for reducing the amount of cytokines in the bloodstream that control immune …