The role of IL-6 and other mediators in the cytokine storm associated with SARS-CoV-2 infection

A Copaescu, O Smibert, A Gibson, EJ Phillips… - Journal of Allergy and …, 2020 - Elsevier
… “TNF” OR “tumor necrosis factor” OR “interferon gamma… cytokine storm” OR “inflammatory
response” OR “septic shock” OR “critically ill” OR “organ dysfunction” OR “infection”) AND (“IL-6

The Nonstructural Protein NSs of Severe Fever with Thrombocytopenia Syndrome Virus Causes a Cytokine Storm through the Hyperactivation of NF-κB

J Khalil, S Yamada, Y Tsukamoto, H Abe… - … and Cellular Biology, 2021 - Taylor & Francis
… of proinflammatory cytokines and chemokines in … cytokine storm in SFTS patients and the
kinetics of cytokines and chemokine induction. Based on these reports, tumor necrosis factor

Deciphering the COVID‐19 cytokine storm: systematic review and meta‐analysis

R Mulchandani, T Lyngdoh… - European journal of …, 2021 - Wiley Online Library
… of estimates), tumour necrosis factor-alpha and T-lymphocyte counts (CD4+ T cells and
CD8+ T cells) that have been widely reported in relation to the cytokine storm in patients having …

[HTML][HTML] Cytokine storm and immunomodulatory therapy in COVID-19: role of chloroquine and anti-IL-6 monoclonal antibodies

M Zhao - International journal of antimicrobial agents, 2020 - ncbi.nlm.nih.gov
… that a cytokine storm (ie higher concentrations of granulocyte-colony stimulating factor, … 1,
macrophage inflammatory protein 1α and tumour necrosis factor α) could be associated with …

Role of SARS-CoV-2-induced cytokine storm in multi-organ failure: Molecular pathways and potential therapeutic options

Y Nazerian, M Ghasemi, Y Yassaghi, A Nazerian… - International …, 2022 - Elsevier
… thorough review of cytokine storm pathophysiology mechanisms … interventions to control
cytokine storm and prevent severe … of the cytokine storm via producing tumor necrosis factor (…

Interplay between interleukin-6 signaling and the vascular endothelium in cytokine storms

S Kang, T Kishimoto - Experimental & molecular medicine, 2021 - nature.com
cytokine storms. Elevated serum levels of IL-1, IL-6, IL-18, interferon (IFN)-γ, and tumor
necrosis factor (TNF)-α are typical features of a cytokine storm. In particular, an elevated level of …

[HTML][HTML] Proinflammatory cytokines levels in sepsis and healthy volunteers, and tumor necrosis factor-alpha associated sepsis mortality: A systematic review and meta …

AA Gharamti, O Samara, A Monzon, G Montalbano… - Cytokine, 2022 - Elsevier
… We need to revisit the paradigm of cytokine storm as the core mechanism of sepsis
pathogenesis. Follow-up studies that critically re-assess the causal role of elevated proinflammatory …

Tumor necrosis factor-alpha exacerbates viral entry in SARS-CoV2-infected iPSC-derived cardiomyocytes

CY Lee, CH Huang, E Rastegari… - International journal of …, 2021 - mdpi.com
… Since the elevated expression of TNF-α has been reported during the initial stages of
SARS-CoV-2 infection and may serve as a key component of the cytokine storm in COVID-19 [21,…

Absence of “Cytokine Storm” in hospitalized COVID-19 patients: A retrospective cohort study

ML Ciampa, TA O'Hara, CL Joel, MM Gleaton… - Infectious Disease …, 2021 - mdpi.com
… reports led to questioning of “cytokine storm” theory in COVID-… exaggerated cytokine response
in the range of a “cytokine storm” … cytokines reported to be involved in “cytokine storm” and …

Plasmin regulation of acute cytokine storm

JM Gomez-Salinero, S Rafii - … Journal of the American Society of …, 2017 - ashpublications.org
… immune modulators, including cyclosporine A, tumor necrosis factor (TNF) inhibitors, or anti–…
of plasmin activation in response to an acute cytokine storm that is the basis of and driver for …