A two-dimensional (2d) systems biology-based discrete liver tissue model: A simulation study with implications for ultrasound elastography of liver fibrosis

Y Wang, J Jiang - Computers in biology and medicine, 2019 - Elsevier
liver fibrosis (from 1.5 m/s [Fibrosis stage 1] to 4 m/s [Fibrosis stage 4]). Similarly, the simulated
… In summary, we found that those systems biology simulated fibrotic liver tissues with and …

[HTML][HTML] Computational simulation of liver fibrosis dynamics

M Yoshizawa, M Sugimoto, M Tanaka, Y Sakai… - Scientific reports, 2022 - nature.com
… and repetitive tissue injury induces liver fibrosis and even … components within two-dimensional
(2D) liver lobules. The … To simulate this diffusion, we designed a simple discrete

[HTML][HTML] A rule-based multiscale model of hepatic stellate cell plasticity: critical role of the inactivation loop in fibrosis progression

M Bouguéon, V Legagneux, O Hazard… - PLOS Computational …, 2024 - journals.plos.org
… the stiffness of tissues, leading to severe liver dysfunction. The final … [24], we conducted
simulation studies using the protocol … With counters, we can use discrete intervals to describe a …

A digital liver twin demonstrating the interplay between biomechanics and cell kinetics can explain fibrotic scar formation

J Zhao, S Hammad, M de Langlard, P Erdoesi, Y Li… - 2023 - hal.science
… considered, or at low resolution sufficiently far away from the liver tissue damage zone.
High resolution cell models permit a higher accuracy of biomechanics at the expense of longer …

“Organ-on-a-chip”-based physiologically relevant pharmacokinetic models

V Tambe, N Desai, K Rajpoot, RK Tekade - Biopharmaceutics and …, 2021 - Elsevier
model compared to that of two-dimensional in vitro cell … candidates involves using traditional
two-dimensional (2D) in vitro … of rapidly perfused tissues like kidney, liver, lungs, and heart) …

Fat and fibrosis as confounding cofactors in viscoelastic measurements of the liver

SS Poul, KJ Parker - Physics in Medicine & Biology, 2021 - iopscience.iop.org
… Wang Y and Jiang J 2019 A two-dimensional (2D) systems biology-based discrete liver
tissue model: a simulation study with implications for ultrasound elastography of liver fibrosis …

Synthetic tissue engineering with smart, cytomimetic protocells

DW Green, JA Watson, B Ben-Nissan, GS Watson… - Biomaterials, 2021 - Elsevier
… synthesized into biological units using synthetic biology-based techniques. For added … hard
matter have developed rapidly onto two-dimensional substrates in three-dimensional space. …

On the soft tissue ultrasound elastography using FEM based inversion approach

SS Eshaghinia, A Taghvaeipour… - Proceedings of the …, 2024 - journals.sagepub.com
… The tissue under quasi-static mechanical stimulus is often idealized as a 2D plane strain …
Finally, the method is applied on 3 liver clinical tissue and it is shown that the method could …

The Important Role of Systems Biology in Neuroscience and Neurology and Its Associated Diseases

M Haripriyaa, K Suthindhiran - Systems Biology Approaches: Prevention …, 2024 - Springer
… (1D) and two-dimensional (2D) nanomaterials have demonstrated … , computational systems
with biology-based learning and … research on human AD brain tissues and animal models

[HTML][HTML] A bio-inspired convolution neural network architecture for automatic breast cancer detection and classification using RNA-Seq gene expression data

TIA Mohamed, AE Ezugwu, JV Fonou-Dombeu… - Scientific Reports, 2023 - nature.com
… , lung, liver, gallbladder and central nervous system. The … ), and SBO-CNN (Biology-based.
The same parameter values of … gene expression data into two-dimensional images, which …