[HTML][HTML] Pyroptotic cell death in SARS-CoV-2 infection: revealing its roles during the immunopathogenesis of COVID-19

M Wang, W Chang, L Zhang… - International Journal of …, 2022 - ncbi.nlm.nih.gov
… cells, the cytokine storm and viral infection-induced cell death … prognosis and attenuating
the risk of death. The appraisal of … may be a novel therapeutic agent for COVID-19. The …

[HTML][HTML] The four horsemen of a viral Apocalypse: The pathogenesis of SARS-CoV-2 infection (COVID-19)

P Domingo, I Mur, V Pomar, H Corominas… - …, 2020 - thelancet.com
… The pathogenesis of coronavirus disease 2019 (COVID-19) … exploding in an actual cytokine
storm. Downregulation of the … of 2019 novel coronavirus: implications for virus origins and …

Effects of sEH inhibition on the eicosanoid and cytokine storms in SARSCoV2‐infected mice

ML Edin, A Gruzdev, JP Graves, FB Lih… - The FASEB …, 2024 - Wiley Online Library
attenuated the SARSCoV- 2- induced eicosanoid storm and … : (1) SARS- CoV- 2 infection
induced profound cytokine and … The cytokine storm in COVID- 19: further advances in our un…

SARS-CoV-2 Spike protein promotes hyper-inflammatory response that can be ameliorated by Spike-antagonistic peptide and FDA-approved ER stress and MAP …

ACY Hsu, G Wang, AT Reid, PC Veerati… - Biorxiv, 2020 - biorxiv.org
cytokine storm), and acute lung injury and acute respiratory … in those with severe COVID-19.
The specific antagonistic … deployed to reduce infection-induced symptoms and pathologies …

[HTML][HTML] The role of cell death in SARS-CoV-2 infection

C Yuan, Z Ma, J Xie, W Li, L Su, G Zhang, J Xu… - Signal transduction and …, 2023 - nature.com
… PDK1 and M, thereby further attenuating PDK1-PKB/AKT interaction in … SARS-CoV-2
infection induced the excess immune response called the cytokine storm among severe COVID-19

Viral mimicry of interleukin-17A by SARS-CoV-2 ORF8

X Wu, T Xia, WJ Shin, KM Yu, W Jung, A Herrmann… - MBio, 2022 - Am Soc Microbiol
… In fact, SARS-CoV-2 infection induced stronger activation of … -17A, suggesting a potential
therapeutic target for COVID-19. … cytokine storm detected in the peripheral blood of COVID-19

Targeting spike protein-induced TLR/NET axis by COVID-19 therapeutic NRICM102 ameliorates pulmonary embolism and fibrosis

WC Wei, CC Liaw, KC Tsai, CT Chiou, YH Tseng… - Pharmacological …, 2022 - Elsevier
cytokine storm and contribute to lung injury [9], [14]. Furthermore, AT2 cell dysfunction or
loss (apoptosis or necrosis) induced by SARS-CoV-2 is … SARS-CoV-2 (S1) infection-induced

Cytokine storm may not be the chief culprit for the deterioration of COVID-19

Y Gao, C Wang, K Kang, Y Peng, Y Luo, H Liu… - Viral …, 2021 - liebertpub.com
… Viral infection-induced cytokine storm was characterized by … pathways and mechanisms
after SARS-CoV-2 infection. … , were commonly applied to attenuate inflammatory response and …

[HTML][HTML] PI3K/Akt/Nrf2 mediated cellular signaling and virus-host interactions: latest updates on the potential therapeutic management of SARS-CoV-2 infection

VS Lekshmi, K Asha, M Sanicas, A Asi… - Frontiers in Molecular …, 2023 - frontiersin.org
… agent of the COVID-19 pandemic, SARS-CoV-2. Understanding … are initiated due to infection
induced oxidative stress, it is … cytokine storms, and prevent inflammatory effects following …

SARS-CoV-2 infection and oxidative stress: Pathophysiological insight into thrombosis and therapeutic opportunities

MS Alam, DM Czajkowsky - Cytokine & Growth Factor Reviews, 2022 - Elsevier
… with the cytokine storm contribute to COVID-19 pathogenesis … In the early phase of COVID-19,
SARS-CoV-2 replication in … underlying SARS-CoV-2 infection-induced oxidative stress, it is …