[HTML][HTML] Inosine: A broad-spectrum anti-inflammatory against SARS-CoV-2 infection-induced acute lung injury via suppressing TBK1 phosphorylation

N Wang, E Li, H Deng, L Yue, L Zhou, R Su… - Journal of …, 2023 - Elsevier
… (SARS-CoV-2)-induced cytokine storms constitute the primary cause of coronavirus disease
19 (COVID-19) … attenuation of cytokine storms and acute inflammatory lung injury induced by …

An overview of recent insights into the response of TLR to SARS-CoV-2 infection and the potential of TLR agonists as SARS-CoV-2 vaccine adjuvants

MEH Kayesh, M Kohara, K Tsukiyama-Kohara - Viruses, 2021 - mdpi.com
… 2 (SARS-CoV-2) has led to coronavirus disease (COVID-19), … its antagonist attenuates
pro-inflammatory cytokine induction … contribute to the cytokine storm observed in COVID-19 [58] …

Type 2 diabetes contributes to altered adaptive immune responses and vascular inflammation in patients with SARS-CoV-2 infection

M Singh, O Barrera Adame, M Nickas… - Frontiers in …, 2022 - frontiersin.org
… help combat the cytokine storm as seen in COVID-19 to help … of both calcitriol and paricalcitol
attenuated TNF-α-dependent … to analyze the pathogenesis of the novel virus. Nowadays, …

An insight into the mechanisms of COVID-19, SARS-CoV2 infection severity concerning β-cell survival and cardiovascular conditions in diabetic patients

A Srivastava, C Rockman-Greenberg, N Sareen… - Molecular and Cellular …, 2022 - Springer
… The outbreak of SARS-CoV-2, COVID-19 has seen successive … between the cytokine storm
and disease severity. Further, this … COVID-19, SARS-CoV2 viral infection induced cytokine

Apigetrin inhibits cytotoxicity and dysregulation of ACE2, IL1α and TGFβ expression induced by recombinant spike protein of SARS-CoV-2

G Luo, W Zhu - World Journal of Advanced Research and Reviews, 2021 - wjarr.com
… the major pathophysiological factors of COVID-19 infection. Our … can attenuate cytotoxicity
induced by SARS-CoV-2 infection. … and cytokine storm associated with SARS-CoV-2 infection. …

… trained by coronavirus infections, DAMP stimulations and regulated by anti-oxidant NRF2 may contribute to inflammations, myelopoiesis, COVID-19 cytokine storms …

Y Shao, J Saredy, K Xu, Y Sun, F Saaoud… - Frontiers in …, 2021 - frontiersin.org
… syndrome coronavirus 2 [SARS-CoV-2, COVID-19 (45)] has … pathogenesis of viral
infection-induced vascular inflammation… ORF6 in icSARS-CoV not only attenuated the activity of …

The role of macrophages in the pathogenesis of SARS-CoV-2-associated acute respiratory distress syndrome

A Kosyreva, D Dzhalilova, A Lokhonina… - Frontiers in …, 2021 - frontiersin.org
… cases of COVID-19, the virus promotes cytokine storm with … focus on SARS-CoV-2-associated
ARDS (COVID-19-ARDS). … , NAMs also regulate infection-induced inflammation through …

SARS-CoV-2 pathogenesis: imbalance in the renin-angiotensin system favors lung fibrosis

MV Delpino, J Quarleri - Frontiers in cellular and infection …, 2020 - frontiersin.org
… of those who survived to COVID-19 outbreak is the development … , favored by a cytokine
storm involving IL-6, IL-10, and TNF-α … In pulmonary viral infection-induced fibrosis, the oxidative …

Of bats and men: Immunomodulatory treatment options for COVID-19 guided by the immunopathology of SARS-CoV-2 infection

MJ Christie, AT Irving, SC Forster, BJ Marsland… - Science …, 2021 - science.org
… , thus attenuating adaptive immune responses (74). Similarly, … Tacaribe virus infection induced
IL1, IL6, and IL8 … those running rampant during COVID-19 and its cytokine storm. Hence, …

… hemodynamic, cytokine and blood cell changes in pigs: an innate immune stimulation model with relevance to cytokine storm syndrome and severe COVID-19

G Kökény, T Bakos, BA Barta, GV Nagy… - International Journal of …, 2023 - mdpi.com
… independent CSS [24,25,26,27,28]; thus, they are manifestations of the immune
derangement, rather than direct consequences of the infection with SARS-CoV-2 virus. …