… novel molecules and possible future drug targets: Currently, α6-containing GABAA receptors
… Therefore, we aim to learn more about α6-containing GABAA receptors. They are mostly …

… neurosteroids are novel drug candidates for epileptic disorders [125, 128]. Consequently,
due to their potent actions on δ -GABA A Rs [128, 129], δ -GABA A Rs are novel therapeutic …

… In the current study, we consider an alternative novel hypothesis… subunit-containing GABA
A (δGABA A ) receptors in neurons. We focus on δGABA A receptors because these receptors …

… the GABA A R subunit combination α3β2γ1 conforms the bulk of GABA A Rs in oligodendrocytes
from rat … Furthermore, we found that these receptors have differential pharmacological …

… of eight GABA A receptor α subunits in zebrafish embryos by in situ hybridization and showed
that most α subunits … the physiological function of GABA A receptors in zebrafish. Antisense …

… One example is a model of the α 1 β 2 γ 2 GABA A R used for the development of novel
drugs [Citation144]. Selective antagonists based on a tricyclic oxazolo-2,3-BZD scaffold were …

… of the human synaptic α1β3γ2L GABA A receptor in complex with PTX, PTX and GABA (PTX/GABA),
BCC, DZP and GABA (DZP/GABA), and ALP and GABA (ALP/GABA). We establish …

… of GABA A Rs are composed of two α subunits, two β subunits, and one γ subunit arranged
as … The mature receptor has a central chloride ion channel gated by GABA neurotransmitter …

… of receptor regulation beyond expression. Advancing our understanding of the factors
regulating GABA A R subunit … , and contribute to the development of novel targeted therapies. …

… GABA receptors, including the mode of α-CBTx antagonism and the signature property for αβ
receptors of … loops responding to GABA, a more upright β-subunit M2 helix occupying the γ-…