… scientific leadership, and rapidly embarked on large scale data collection and analysis to
build draft atlases… should aim to produce decision trees that serve to guide researchers to …

… in a tree of airways and alveoli, mirrored with trees of blood and … Lung Cell Atlas project will
be used to define cell type … the Human Cell Atlas, launched in 2016, now involves scientists …

… comprehensive cell atlas of human development (10), we set out to generate single-cell
atlases … As an illustrative example of how these data can be used to explore cell trajectories, we …

… Cell atlas datasets will serve as a reference for annotating cell types and states in future
experiments. … Our reference sample simulated common scenarios in cell atlas projects, including …

… reference. The HLCA expands our understanding of the healthy lung and its changes in
disease and can be used as a reference … from more distal parts of the bronchial tree (Fig. 4c). In …

… key branching points along the tree of life. Besides applications in evolutionary biology, we
anticipate SAMap can catalyze the annotation of new cell atlases from non-model organisms, …

… Reference cell locations do not change during mapping. e … embedding can be used for
downstream transfer of reference-… cell atlases, we built a reference of 1.39 million cells (270 …

… Here, statistical models can be used to directly analyze raw … this work will become a reference
for method developers, who can … developed methods on atlas-level data integration tasks. …

… cell data science is the mapping of single cells to a reference … In this respect, mouse atlases
could serve as scaffolds to … , and a custom integration tree to initiate alignment from the …

… (D) Transcriptomics-derived hematopoietic tree showing the … The pTPM values can be used
to investigate the abundance … of the Human Protein Atlas program and the Science for Life …