… NDM-1 is essential in the hydrolysis of β-lactam antibiotics [56]. The electrophilic zinc ions in
the NDM-1 enzyme and the electron-rich substituent of NDM-1 … of the superbug NDM-1 and …

… , NDM-1) resistance gene is a new type of “superbug”, which can hydrolyze almost all β-lactam
antibiotics, … In this review, the research progress of NDM-1 enzyme and its inhibitors in the …

… NDM-1 have been labeled as superbugs because it confers upon them resistance to a broad
range of β-lactam antibiotics… 3 μM NDM-1 enzymes) and then the enzymes were dialysed …

… carrying NDM-1. Understanding the mechanism of antibiotic degradation by NDM-1 protein
… With dimensions of 50 × 40 × 40 Å, the NDM-1 enzyme is a compact globular structure that …

… pumps to increase antibiotic excretion; and (4) degradation of the antibiotic by bacterial …
with the other enzymes tested. The X-ray crystal structures of the NDM-1 enzyme in complex with …

… possessing the gene for the NDM-1 enzyme is a serious and … , they are deemed a superbug,
and treatment is challenging … NDM-1 has accelerated the antibiotic resistance pandemic. …

… Discovering new NDM-1 inhibitors as antibiotic adjuvants is … The NDM-1 enzyme was
expressed and purified as … of effective MBL inhibitors against NDM-1-producing superbugs. In this …

… antibiotics, including carbapenems, fluoroquinolones, and aminoglycosides (9, 10). The rapid
spread of NDM-1 and NDM-1 … of NDM enzymes is attributed as well to the fact that NDM-1, …

… about antibiotic resistance, NDM-1, mechanism of antibiotic … active site of the enzyme, the
NDM-1 enzyme is ready again (… evaluated as NDM-1 inhibitors that help to degrade bacterial …

… , NDM-1 gene usually shares the same plasmid with extra resistance markers, which compromise
activity of other antibiotics apart from NDM-1 … MBLs (including NDM-1) both in enzyme …