Malaria vaccine: prospects and challenges

AO Hassan, OV Oso, EI Obeagu… - … University journal of …, 2022 - madonnauniversity.edu.ng
Malaria is a life-threatening disease caused by the plasmodium genus, malaria can cause
a range of symptoms and life –threatening complications so an early diagnosis is crucial. In …

Progress in the development of subunit vaccines against malaria

M Skwarczynski, S Chandrudu, B Rigau-Planella… - Vaccines, 2020 - mdpi.com
… falciparum AMA-A- and CSP-derived peptides as a malaria vaccine, ten Tanzanian adults
… living in a malaria-endemic region were immunized with one or two doses of the vaccine on …

RTS, S: the first malaria vaccine

F Zavala - The Journal of clinical investigation, 2022 - Am Soc Clin Investig
… consensus that major improvements are necessary to develop a vaccine that is likely to have
a greater epidemiological impact in endemic areas. Since the development of RTS,S in the …

Safety, immunogenicity and efficacy of PfSPZ Vaccine against malaria in infants in western Kenya: a double-blind, randomized, placebo-controlled phase 2 trial

…, D Akach, T Sang, JR Gutman, EL Nzuu, A Dungani… - Nature Medicine, 2021 - nature.com
… exposure to malaria would have improved immunity and protection. We conducted a multi-…
and efficacy of the PfSPZ Vaccine in infants in a high-transmission malaria setting in western …

[HTML][HTML] The RH5-CyRPA-Ripr complex as a malaria vaccine target

RJ Ragotte, MK Higgins, SJ Draper - Trends in parasitology, 2020 - cell.com
A highly effective malaria vaccine would be one way to achieve further reductions in the global
malaria … confers immunity against malaria suggests that a malaria vaccine is conceivable [ …

Malaria vaccines since 2000: progress, priorities, products

PE Duffy, J Patrick Gorres - npj Vaccines, 2020 - nature.com
Malaria vaccine development entered a new era in 2015 … the first human anti-parasite
vaccine to pass regulatory scrutiny. … of vaccines for malaria elimination, or a so-called vaccine to …

A monoclonal antibody for malaria prevention

…, O Trofymenko, Z Hu, A Campos Chagas… - … England Journal of …, 2021 - Mass Medical Soc
… Here, we present evidence in humans that malaria can be prevented from 4 to 36 weeks
after a single administration of a monoclonal antibody against the major protein covering the …

Malaria vaccines: progress to date

DI Stanisic, MF Good - BioDrugs, 2023 - Springer
… and deployment of a highly effective malaria vaccine that is … A highly effective malaria
vaccine that can induce long-lasting protective immunity will contribute to a reduction in malaria-…

The challenges of a circumsporozoite protein-based malaria vaccine

D Chatterjee, IA Cockburn - Expert Review of Vaccines, 2021 - Taylor & Francis
… are a promising approach for malaria vaccination. However, for a vaccine that is a truly
useful weapon in the fight against malaria transmission we will need to either significantly …

[HTML][HTML] The role of different components of the immune system against Plasmodium falciparum malaria: Possible contribution towards malaria vaccine development

WL Mandala, V Harawa, F Dzinjalamala… - Molecular and …, 2021 - Elsevier
… Thus, the search for a more robust and effective malaria vaccine still continues and a better
… the parasite, could be crucial in rational vaccine design. This review therefore compiles what …