Deciphering the acetylation code of p53 in transcription regulation and tumor suppression

Z Xia, N Kon, AP Gu, O Tavana, W Gu - Oncogene, 2022 - nature.com
… CTD acetylation can induce p53 transcriptional activation and tumor suppression through
/or multisite phosphorylation of p53 can recruit acetyltransferase p300/CBP to promote p53

The role of acetylation sites in the regulation of p53 activity

Y Wang, Y Chen, Q Chen, X Zhang, H Wang… - Molecular biology …, 2020 - Springer
… the first identified acetyltransferase of p53 which acetylates p53 at … /or cofactor recruitment
to particular p53 response element [… transcriptional coactivator of p53, which acetylates p53 at …

An unexpected role for p53 in regulating cancer cell–intrinsic PD-1 by acetylation

Z Cao, N Kon, Y Liu, W Xu, J Wen, H Yao, M Zhang… - Science …, 2021 - science.org
… -mediated PD-1 transcription. Acetylated p53 preferentially recruited acetyltransferase
-mediated PD-1 expression, we first focused on the acetyltransferase p300/CBP and TIP60. …

[PDF][PDF] Acetylation of Smad1 promotes tumorigenesis and chemoresistance via competitive attenuation of p300-mediated p53 acetylation in glioblastoma

L Gong, D Xu, Z Pu, B Zhang, Y Yin, L Ji, J Wang, Y Hu… - 2022 - scholar.archive.org
… Due to the physical interaction between the acetyltransferase p300 and Smad1 [29–31],
we … , et al., Acetylation of p53 activates transcription through recruitment of coactivators/histone

Targeting the acetylation signaling pathway in cancer therapy

F Dang, W Wei - Seminars in cancer biology, 2022 - Elsevier
… It has been well documented that the recruitment of histone … -terminal acetylation, it is
catalyzed by Nα-acetyltransferase (… , acetylation of p53 at K120 after DNA damage induces p53-…

Epigenetic alterations upstream and downstream of p53 signaling in colorectal carcinoma

MT Tomicic, M Dawood, T Efferth - Cancers, 2021 - mdpi.com
… HDAC1 and inhibits HDAC1 recruitment to the TP53 promoter and p53 acetylation [87,88]. …
The acetylation of p53 at lysine 320 is achieved by histone acetyltransferase, PCAF (p300-…

Experimental Insights into the Interplay between Histone Modifiers and p53 in Regulating Gene Expression

HM Kim, X Zheng, E Lee - International Journal of Molecular Sciences, 2023 - mdpi.com
p53 is required for the binding of acetyltransferase Tip60 to p53 and the subsequent acetylation
of p53, … This suggests that a cascade of acetylation, in which p53-dependent recruitment

The role of histone protein acetylation in regulating endothelial function

Z Fang, X Wang, X Sun, W Hu, QR Miao - … in Cell and Developmental …, 2021 - frontiersin.org
acetyltransferase confirmed to link histone acetylation to … ), ROS inducer, upregulates p53
and acetylation of H3K14 and … Fas ligand via recruiting p300 and acetylated histones H3 and …

The Interplay between Histone Modifiers and p53 in Regulating Gene Expression

HM Kim, X Zheng, E Lee - 2023 - preprints.org
… K372-p53 enhances subsequent acetylation of p53 by p300 … potential to modulate 173 p53
transcriptional 174 activity in a … coactivator 178 for p53 by recruiting 179 histone acetyltrans- …

p53 at the crossroads between different types of HDAC inhibitor-mediated cancer cell death

M Mrakovcic, J Kleinheinz, LF Fröhlich - International journal of molecular …, 2019 - mdpi.com
… These interfere with histone acetyltransferase- and deacetylase-mediated acetylation of
both histone and non-histone proteins, and thereby exert a wide array of HDACi-stimulated …