… goblet cell differentiation, we measured changes in SPDEF and … almost no expression of
SPDEF in the lungs of MUC5B −/− … Gas–liquid interface culture of primary airway epithelial cells …

… goblet transdifferentiation of secretory airway epithelial cells. … the goblet cell fate program,
directly repressing the SPDEF … damage, increased inflammation, and matrix remodeling. We …

… inflammation, goblet cell hyperplasia, and mucus … in the differentiation of airway epithelial
cells during lung development … expression of Spdef, a regulator of goblet cell differentiation (…

… native airway epithelium may introduce cellular differentiation … inflammatory responses in
both airway epithelial cells and T … decreases SPDEF protein levels, goblet cell differentiation …

… airway epithelium and their role during airway inflammation. … goblet cell differentiation, but
one to be highlighted is SPDEF (… that the NE cell hyperplasia seen in young children with lung …

… Goblet cell and 251 tissue inflammation indexes were scored on coded slides by an … of
SPDEF or FOXA3 in airway epithelial cells in mice mediate goblet cell 582 differentiation, …

… and mature goblet cell markers (SOX2, CA2, and SPDEF). … goblet cell hyperplasia in
inflammation of the allergic airway. … hyperplasia and loss of cilia in the airway epithelium (9, 10), …

… Specifically, SPDEF is essential for goblet cell differentiation and the production of … airways
of the lung; however, their differentiation can be induced by acute and chronic inflammatory …

… that VP has inhibited airway epithelial thickness and cell size in … SPDEF is indispensable
for airway goblet cell differentiation … Foxf genes integrate tbx5 and hedgehog pathways in the …

… of chronic pulmonary inflammatory diseases including … , MUC5B and SPDEF during
club-to-goblet cell transition. c Venn … Goblet cell metaplasia in the lung airway epithelium has been …