SARS-CoV-2 infection causes COVID-19. Several clinical reports have linked COVID-19
during pregnancy to negative birth outcomes and placentitis. However, the
pathophysiological mechanisms underpinning SARS-CoV-2 infection during placentation
and early pregnancy are not clear. Here, to shed light on this, we used induced trophoblast
stem cells to generate an in vitro early placenta infection model. We identified that
syncytiotrophoblasts could be infected through angiotensin-converting enzyme 2 (ACE2) …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causing
coronavirus disease 2019 (COVID-19) has caused a global health crisis. The primary site of
infection is in the respiratory tract but the virus has been associated with a variety of
complications involving the gastrointestinal and cardiovascular systems. Since the virus
affects a variety of tissue types, there has been interest in understanding SARS-CoV-2
infection in early development and the placenta. ACE2 and TMPRSS2, two genes that are …