Could SARS-CoV-2 blocking of ACE2 in endothelial cells result in upregulation of CX3CL1, promoting thrombosis in COVID-19 patients?

S Rivas-Fuentes, VJ Valdés, B Espinosa… - Medical hypotheses, 2021 - Elsevier
… could cause the accumulation of angiotensin II, which ultimately diminishes the … intercellular
adhesion molecule (ICAM-1), vascular cell adhesion molecule-1 (VCAM), vascular adhesion

Vitamin D Inhibits IL-6 pro-atherothrombotic effects in human endothelial cells: A potential mechanism for protection against COVID-19 infection?

G Cimmino, S Conte, M Morello, G Pellegrino… - Journal of …, 2022 - mdpi.com
… the surface expression of intracellular adhesion molecule-1 (ICAM1), vascular cell adhesion
… Moreover, this cytokine induces expression of the soluble adhesion molecules ICAM-1 and …

Direct activation of endothelial cells by SARS-CoV-2 nucleocapsid protein is blocked by Simvastatin

Y Qian, T Lei, PS Patel, CH Lee… - Journal of …, 2021 - Am Soc Microbiol
… -CoV-2 viral proteins that potently activate human endothelial … N protein-induced ICAM-1
expression, which include simvastatin, … -cell lysates were harvested 8 h after NP stimulation and …

[HTML][HTML] LCZ696 ameliorates lipopolysaccharide-induced endothelial injury

A Gao, Y Wang, X Gao, W Tian - Aging (Albany NY), 2021 - ncbi.nlm.nih.gov
… -induced expressions of vascular cell adhesion molecule 1 (VCAM… of NP proteins and
Angiotensin II. Neprilysin inhibitors have … Our findings reveal that LCZ696 inhibits all the tested pro-…

Thrombin induces angiotensin II-mediated senescence in atrial endothelial cells: impact on pro-remodeling patterns

H Hasan, SH Park, C Auger, E Belcastro… - Journal of Clinical …, 2019 - mdpi.com
… and Platelet endothelial cell adhesion molecule-1 (PECAM1) … NF-κB-dependent expression
of ICAM-1 and VCAM-1 in … by thrombin induced the synthesis of TGF-β by human atrial …

Molecular interactions, bioavailability, and cellular mechanisms of angiotensin‐converting enzyme inhibitory peptides

H Fan, W Liao, J Wu - Journal of Food Biochemistry, 2019 - Wiley Online Library
… (c) View of human tACE showing the deep narrow channel toward … intercellular adhesion
molecule-1 (ICAM-1) and vascular cell … Over stimulation by Ang II in vSMCs leads to aberrant …

Endothelin B Receptor is Involved in Endothelin-1 Induced Cell Response in Vascular Smooth Muscle Cells

Q Chen, Y Lu, Y Qiao, G Chen… - Journal of Nanoscience …, 2019 - ingentaconnect.com
intercellular adhesion molecule 1 (ICAM-1) and vascular cell … atherosclerosis as angiotensin
II, PDGF-A, TNF- and … In this study, ET-1 could also stimulate of endothelin-1 mRNA and …

The effects of known cardioprotective drugs on proinflammatory cytokine secretion from human coronary artery endothelial cells

MJ Haas, M Jurado-Flores, R Hammoud… - American journal of …, 2019 - journals.lww.com
expression of various vascular adhesion molecules (such as vascular cell adhesion molecule
1 (VCAM1) and intercellularAngiotensin II also stimulates the synthesis of intercellular

Selective inhibition of histone deacetylase 8 improves vascular hypertrophy, relaxation, and inflammation in angiotensin II hypertensive mice

HJ Kee, Y Ryu, YM Seok, SY Choi, S Sun, GR Kim… - Clinical …, 2019 - Springer
… -1 and ICAM-1 decreased in the aortas of angiotensin II-infused … molecule-1 (ICAM-1), and
platelet endothelial cell adhesion … PCI34051 inhibits the expression of adhesion molecules in …

Dexmedetomidine protects cells from Angiotensin II-induced smooth muscle cell phenotype switch and endothelial cell dysfunction

M Dai, X Zhu, S Zeng, Q Liu, R Hu, L Huang, Y Wang… - Cell Cycle, 2023 - Taylor & Francis
… with anti-intercellular adhesion molecule 1 (ICAM-1) antibody (… of NF-κB in Ang II-stimulated
ECs. As displayed by western … of cell adhesion molecules (ICAM-1) and suppressed the …