… Efforts to find drugs that improve the healthspan by targeting the pathogenesis of aging …
status of aging research and the development of potential drugs for aging-related diseases, such …

… However, the molecular mechanisms underlying these characteristics of longevity and
resistance to age-related diseases (cancer, neurodegeneration, immunosenescence, metabolic …

… conditions where the underlying insult is much less clear. For example, for a condition like
Parkinson's disease, the animal model is a model … Such considerations may contribute to the …

… and the implication of NF-κB activation in the development of … mouse models of components
of the NF-κB pathway about the relationship of NF-κB with ageing, with age-related diseases…

… animal models of different human CNS diseases. In mouse models of Alzheimer’s disease,
… the sirtuin family members are gaining significance in human biology and disease. All of the …

… Analogous considerations also apply to many other age-related … , mouse models with
persistent expression of Wnt1, mouse models with conditional deletion of Tsc1 or mouse models of …

… or organismal aging, as well as the pathophysiologies of diverse age-related diseases (…
span and reduced the risk of age-related pathologies in a mouse model, suggesting a direct link …

… Predicted upstream regulators of these gene expression profiles were also consistent with
senescence in human AD and transgenic AD mouse models. In brains from humans with AD, …

… for research purposes under appropriate ethical considerations, … will contribute to the
occurrence of age-related diseases. … aging model organisms, including small animal models and …

… While some of these factors can also result from senescence, improved experimental
techniques and new animal models have expanded our knowledge about causes and …