… underlying endothelial dysfunction in diabetes and may serve … arginase as a key mediator
in endothelial dysfunction and … diseases, especially type 2 diabetes, atherosclerosis and …

… endothelial dysfunction in type 1 and type 2 diabetes (T1DM … effect of arginase inhibition
on vascular function, EDV and EIDV … 120 min intra-arterial infusion of the arginase inhibitor N …

… However, the role of arginase in elderly human subjects in vivo with regard to … endothelial
function is unclear. We hypothesized that arginase inhibition improves endothelial function in …

… completely prevented the increase in arginase activity and … diabetic patients through
increasing NO levels and thus maintaining vascular function possibly through an arginase inhibition …

… of T2DM as well as in the plasma of patients with T2DM and microvascular complications [8,…
, shown that arginase inhibition improves endothelial function in several patient populations …

… Recently, it also has been reported to improve vascular function in diabetics by decreasing
arginase activity in cavernous tissue and raising NO levels [168]. L-norvaline has minimal …

… control on endothelial function and the effect of arginase inhibition in patients with T2DM (Mahdi
et al., 2018), 16 T2DM patients at poor glycemic control (T2DM PGC) and 16 T2DM …

… -dependent NOS-mediated dilation of retinal arterioles during diabetes, whereas … vascular
arginase may improve endothelial function of retinal arterioles during early onset of diabetes…

… from the eNOS to the arginase pathway with its enhanced arginase degradation, as an …
the downregulation of arginase improves endothelial function among patients with DM and …

… arginase inhibition improves vascular function in animal models and patients with diabetes
[[… This protective effect of arginase inhibition could be blocked by eNOS inhibition, suggesting …