… Activated HRAS induces the invasive phenotype in breast … ) cooperates with HRAS to induce
metastatic breast cancer (61)… in metastatic progression and poor clinical outcome of luminal …

… breast cancer [5], colon carcinoma [6], non-small cell lung … In Bmi1/Ras-induced mouse HCC,
Bmi1 was highly expressed … into an invasive phenotype, and metastatic dissemination [25]. …

… on breast cancer cell invasion is achieved by inducing … that Bmi1 works with HRas in
MCF-10A cells to aggressively … , CK2α and Bmi1 cooperated to increase ovarian cancer cell …

… development in head and neck cancer patients and cooperates … of BMI1 together with H-Ras
did induce an aggressive and metastatic phenotype, with the unusual occurrence of breast …

… cascade which induces aggressive phenotypes in TNBC cells. … complex proteins, such as
BMI1 and suppressor of zeste 12 … sarcoma viral oncogene homologue (H-RAS) and the high …

… Metastatic in vivo models of breast cancer additionally demonstrate that BMI1 collaborates
with H-RAS … we took two approaches to rescue the phenotype of BMI1 inhibition. First, in Rh28 …

… BMI1 and suppressor of zeste 12 homologue (SUZ12) [176,181]. Maintaining the BCSC
phenotype and controlling BC metastasis … virus oncogene homologue (H-RAS) and high mobility …

… Brain tumors represent a leading cause of cancer mortality, … our collective fight against
brain cancer. I am most grateful for … of 6-10 weeks has been observed when targeting H-Ras …

… well-known cancer genes, such as TP53 and PIK3CA, breast cancers … Despite this
heterogeneity, the majority of breast cancer … We induced the expression of these BRCA1 proteins …

… We show that BMI1 is required for melanocyte stem cell (… these cellular phenotypes highlighted
a major role for BMI1 in … of breast cancer, driven by overexpression of oncogenic H-Ras (…