Immunosenescence: A systems-level overview of immune cell biology and strategies for improving vaccine responses

SN Crooke, IG Ovsyannikova, GA Poland… - Experimental …, 2019 - Elsevier
… to improve vaccine responses among the aging population. … With respect to the study of
immune responses, we and … how the immune system responds to vaccination and whether these …

Immunosenescence and human vaccine immune responses

SN Crooke, IG Ovsyannikova, GA Poland… - Immunity & …, 2019 - Springer
immune system suffers equally from the effects of biologicalvaccines act to bolster the
immune response. As the field of vaccinology races to keep pace with the aging global population

Targeting inflammation and immunosenescence to improve vaccine responses in the elderly

B Pereira, XN Xu, AN Akbar - Frontiers in immunology, 2020 - frontiersin.org
… Four vaccines are currently recommended for individuals … the effects of aging on immune
responses to vaccination and discuss… The biological significance of the acquisition of innate-like …

The immune response to influenza in older humans: beyond immune senescence

JE McElhaney, CP Verschoor, MK Andrew, L Haynes… - Immunity & …, 2020 - Springer
… hospitalization in the general population of older adults. A recent study … against influenza in
vaccinated older adults. In multiple … of stimulated PBMC and biological activity of the cytolytic …

Influence of immune aging on vaccine responses

CE Gustafson, C Kim, CM Weyand… - Journal of Allergy and …, 2020 - Elsevier
… All modern vaccines work by tricking our immune system into … the aging population. Moreover,
directly comparing the … circumstances independent of biological age including chronic viral …

Factors that influence the immune response to vaccination

P Zimmermann, N Curtis - Clinical microbiology reviews, 2019 - Am Soc Microbiol
… There is substantial variation between individuals in the immune response to vaccination.
In this review, we provide an overview of the plethora of studies that have investigated factors …

Aging, immunity, and COVID-19: how age influences the host immune response to coronavirus infections?

V Bajaj, N Gadi, AP Spihlman, SC Wu, CH Choi… - Frontiers in …, 2021 - frontiersin.org
system in the body, natural aging is accompanied by progressive biological changes in the
immune system … a key lymphocyte population of the adaptive immune system. By recognizing …

Sex differences in older adults' immune responses to seasonal influenza vaccination

EA Voigt, IG Ovsyannikova, RB Kennedy… - Frontiers in …, 2019 - frontiersin.org
… clues to the biological source(s) of sex differences in immune responses to influenza … In a
systems biology analysis of data from 91 young and old individuals by Furman et al. (14), high …

Understanding immunosenescence and its impact on vaccination of older adults

JC Allen, FR Toapanta, W Chen, SM Tennant - Vaccine, 2020 - Elsevier
… from individuals ≥65 years old provide evidence of a dysregulated innate immune system
… provide insight into the biology of immune aging, in which older adults may require more …

[PDF][PDF] Hallmarks of improved immunological responses in the vaccination of more physically active elderly females.

G Choon Lim Wong, V Narang, Y Lu… - Exercise immunology …, 2019 - eir-isei.de
… co-morbidities between active and sedentary elderly individuals in our community dwelling
… were not statistically different between active and sedentary elderly individuals in this study. …