Multinational Enterprises (MNEs) use social media to reach a global audience. Simultaneously, Corporate Social Responsibility (CSR) has become an important feature of MNEs’ communications with stakeholders via social media. It is, therefore, important to understand the country and industry level differences in how stakeholders engage with CSR communications of MNEs via social media. We examine this across four countries and three industries by focusing on stakeholders’ engagement with CSR (vs. non-CSR) posts on Twitter. We find significant differences across industries within countries for three separate aspects of behavioural engagement (likes, retweets and replies). In addition, CSR posts have a positive effect on stakeholder engagement based on likes and retweets at the industry-within-country level. Moreover, CSR posts are not fully effective in developed countries. Hence, achieving legitimacy through CSR on social media is a complex challenge, requiring a nuanced understanding of stakeholder reactions based on specific industry and country contexts.