… luciferase activity using the activity of Renilla luciferase. … Hypoxia-inducible factor-1 (HIF-1)
is a crucial oxygen-sensitive … required to form tubular structures [14,15]. In the present study, …

… of EC angiogenesis (Figure 6A, a) and adhesion (Figure 6A, b). Second, we proved that Cul
5 (10 ng/mL) enhances the angiogenesis … In summary, Cul 5 promotes EC angiogenesis and …

… of elongin B, elongin C, CUL2, RBX1, and an E2 ubiquitin-protein … Attempts at therapeutic
angiogenesis involving delivery of … activity of hypoxia-inducible factor. Genes Dev 16:1466–71 …

… adaptation to hypoxia is the hypoxia-inducible factor 1 (HIF-1). … In the current study, we
successfully demonstrated that CUL2 … -3p and CUL2, we conducted luciferase activity assays. We …

… ubiquitinated by pVHL-related elongin BC-Cul2 ubiquitin ligase complex. Hydroxylated HIF-…
the mechanism of its action has been reported to be closely related to anti-angiogenesis (62)…

… the elongins (B and C), CUL2, and RBX1. The outcome for HIF-… HIF transcriptional activity,
tumor angiogenesis, growth, and … -2α in MM cells increases angiogenesis in tumor xenografts, …

… is closely associated with angiogenesis, tumor stage, treatment … After transfection for 48 h,
the luciferase activity was assessed … CUL2 is down-regulated in GC tissues and is an essential …

… oxygen supply through angiogenesis and increased … required for peptides to be hydroxylated
in vitro. While hypoxia or pharmacologic hydroxylase activity increase basal NF-κB activity…

… the transcriptional activity of Nrf2 downstream targets. … Of note, we demonstrate that
p62 is necessary to stabilize … kappa light-chain-enhancer of activated B cell, and the Vhl-Cul-2 …

… Recent evidence suggests that FIH is required to directly modify hARD1/NAA10, at W38, …
In line, LSD1 was then found to upregulate HIF-1α-dependent angiogenesis by increasing CBP, …