[HTML][HTML] CaMKII/calpain interaction mediates ischemia/reperfusion injury in isolated rat hearts

HT Lu, RQ Feng, JK Tang, JJ Zhou, F Gao… - Cell Death & Disease, 2020 - nature.com
… to prevent Ca 2+ paradox-induced heart injury. In contrast, the … an essential element in
CaMKII-elicited calpain activation. In … Ca 2+ is not the unique factor governing calpain activity, as …

[HTML][HTML] Pharmacological conditioning of the heart: an update on experimental developments and clinical implications

S Roth, C Torregroza, K Feige, B Preckel… - International journal of …, 2021 - mdpi.com
… The exact mechanism of this paradox is still underexplored. One … effects against myocardial
I/R injury by preconditioning with … rat heart I/R [69]. Similar results were observed in a working …

Atrial-paced, exercise-similar heart rate envelope induces myocardial protection from ischaemic injury

Z Zhu, Z Gao, B Chen, DD Hall, R Minerath… - EP …, 2022 - academic.oup.com
preconditioning (IPC) refers to interventions that protect the … intermittent HR acceleration
stimulus elicits a myocardial adaptation … The apparent paradox presented by the association of …

A state-of-the-art review of the current role of cardioprotective techniques in cardiac transplantation

PP Cullen, SS Tsui, NM Caplice… - … and thoracic surgery, 2021 - academic.oup.com
… The major modulating pathways have been elicited and, … Ischaemic preconditioning. A brief
period of reperfusion in … ROS production is impaired in its absence, but this is paradoxical as …

Endless Journey of Adenosine Signaling in Cardioprotective Mechanism of Conditioning Techniques: Clinical Evidence

K Kumar, N Singh, HN Yadav… - Current Cardiology …, 2023 - ingentaconnect.com
Ca2+ preconditioning elicits a unique protection against the Ca2+ paradox injury in rat heart.
Role of adenosine. Fixed… Calcium preconditioning elicits strong protection against ischemic …

Controlling reperfusion injury with controlled reperfusion: Historical perspectives and new paradigms

DM Fischesser, B Bo, RP Benton, H Su… - Journal of …, 2021 - journals.sagepub.com
… However, preconditioning is not a feasible clinical therapy … pressure, it is also possible to
elicit beneficial effects by modifying the … This observation leads to the so-called oxygen paradox: …

[HTML][HTML] Mitochondrial quality control in cardiac-conditioning strategies against ischemia-reperfusion injury

WR García-Niño, C Zazueta, M Buelna-Chontal… - Life, 2021 - mdpi.com
… IPC elicits a bi-phasic pattern of cardioprotection. The first phase … In rats with myocardial
I/R injury, preconditioning or … The role of mitophagy in reperfusion injury is paradoxical, as …

[HTML][HTML] Mitochondrial calcium in cardiac ischemia/reperfusion injury and cardioprotection

E Bertero, TA Popoiu, C Maack - Basic Research in Cardiology, 2024 - Springer
Ca 2+ handling, its alterations during cardiac I/R injury, and … during hypoxia, a seeming
paradox when considering the … observed through interactions between distinct ROS sources. …

Perioperative cardioprotection: general mechanisms and pharmacological approaches

C Torregroza, A Raupach, K Feige… - Anesthesia & …, 2020 - journals.lww.com
… The typical paradox of ischemic conditioning—a sublethal injury leads to … against I/R
injury by preconditioning with milrinone or levosimendan are fully abolished by propofol in rats. …

Myocardial protection in cardiac surgery: a comprehensive review of current therapies and future cardioprotective strategies

P Chiari, JL Fellahi - Frontiers in Medicine, 2024 - frontiersin.org
rats subjected to 1 or 3 cycles of ischemic preconditioning (… acidosis to prevent the pH
paradox phenomenon, and gentle … myocardial injury in patients undergoing cardiac surgery with …