Impacts of cannabinoid epigenetics on human development: reflections on Murphy et. al.'cannabinoid exposure and altered DNA methylation in rat and human sperm' …

AS Reece, GK Hulse - Epigenetics, 2019 - Taylor & Francis
… lab (‘Cannabinoid exposure and altered DNA methylation in rat and human sperm’ Epigenetics
… epigenetic effects of cannabis use on sperm in man parallel those in rats and showed …

[HTML][HTML] Sperm DNA methylation alterations from cannabis extract exposure are evident in offspring

R Schrott, JL Modliszewski, AB Hawkey… - Epigenetics & …, 2022 - Springer
… Using a rat model, we found significant changes to sperm DNA methylation in THC exposed
… support for the heritable effects of THC exposure in rats at autism candidate gene Dlgap2 [20…

[HTML][HTML] Epigenetic alterations in cytochrome P450 oxidoreductase (Por) in sperm of rats exposed to tetrahydrocannabinol (THC)

KS Acharya, R Schrott, C Grenier, Z Huang… - Scientific reports, 2020 - nature.com
… (THC) exposure prior to reproduction. This study determined if chronic THC exposure alters
sperm DNA methylation (… Adult male rats underwent oral gavage with THC or vehicle control. …

[HTML][HTML] Sperm DNA methylation altered by THC and nicotine: Vulnerability of neurodevelopmental genes with bivalent chromatin

R Schrott, M Rajavel, K Acharya, Z Huang, C Acharya… - Scientific reports, 2020 - nature.com
… differential DNA methylation in sperm of rats exposed to delta-9-… DNA methylation in sperm
of rats exposed to 2 mg/kg nicotine, a dose mimicking moderate tobacco smoking in humans. …

Cannabis use is associated with potentially heritable widespread changes in autism candidate gene DLGAP2 DNA methylation in sperm

R Schrott, K Acharya, N Itchon-Ramos, AB Hawkey… - Epigenetics, 2020 - Taylor & Francis
… that cannabis use in humans, and THC exposure in rats, is … significantly altered DNA
methylation in the sperm of cannabis … we identified as having altered DNA methylation. The first …

Refraining from use diminishes cannabis-associated epigenetic changes in human sperm

R Schrott, SK Murphy, JL Modliszewski… - Environmental …, 2021 - academic.oup.com
… in humans between cannabis use and altered sperm DNA … A sperm DNA methylation
epimutation biomarker panel for … using a rat model of paternal preconception exposure to THC and …

Inheritance of paternal lifestyles and exposures through sperm DNA methylation

KW Greeson, KMS Crow, RC Edenfield… - Nature Reviews …, 2023 - nature.com
… with altered DNA methylation at non-imprinted genes in sperm, … Cannabis usage was
associated with dramatic changes in … female rat, decreased spermatogenic cell number and sperm

Cannabis use and the sperm epigenome: a budding concern?

R Schrott, SK Murphy - Environmental Epigenetics, 2020 - academic.oup.com
… inheritance of an altered sperm DNA methylation pattern, we turned to a rat model of THC
exposure. We first looked at the sperm of male rats exposed to 4 mg/kg THC (a dose reflecting …

The preconception environment and sperm epigenetics

C Marcho, OA Oluwayiose, JR Pilsner - Andrology, 2020 - Wiley Online Library
… suggests that altered DNA methylation and chromatin … , THC-induced changes in rat sperm
methylation162 overlapped with methylation changes previously reported in the brain of rat

[HTML][HTML] The epigenetics of the endocannabinoid system

R Meccariello, A Santoro, S D'Angelo… - International journal of …, 2020 - mdpi.com
… observation, Δ 9 THC exposure-dependent changes in the DNA methylation of rat sperm [80] …
On the other hand, the altered DNA methylation of both GPR55 and CB1 encoding genes, …