R Schrott, JL Modliszewski, AB Hawkey… - Epigenetics & …, 2022 - Springer
… Using a rat model, we found significant changes to spermDNAmethylation in THCexposed … support for the heritable effects of THCexposure in rats at autism candidate gene Dlgap2 [20…
KS Acharya, R Schrott, C Grenier, Z Huang… - Scientific reports, 2020 - nature.com
… (THC) exposure prior to reproduction. This study determined if chronic THCexposure alters spermDNAmethylation (… Adult male rats underwent oral gavage with THC or vehicle control. …
R Schrott, M Rajavel, K Acharya, Z Huang, C Acharya… - Scientific reports, 2020 - nature.com
… differential DNAmethylation in sperm of ratsexposed to delta-9-… DNAmethylation in sperm of ratsexposed to 2 mg/kg nicotine, a dose mimicking moderate tobacco smoking in humans. …
R Schrott, K Acharya, N Itchon-Ramos, AB Hawkey… - Epigenetics, 2020 - Taylor & Francis
… that cannabis use in humans, and THCexposure in rats, is … significantly alteredDNA methylation in the sperm of cannabis … we identified as having alteredDNAmethylation. The first …
… in humans between cannabis use and alteredspermDNA … A spermDNAmethylation epimutation biomarker panel for … using a rat model of paternal preconception exposure to THC and …
… with alteredDNAmethylation at non-imprinted genes in sperm, … Cannabis usage was associated with dramatic changes in … female rat, decreased spermatogenic cell number and sperm …
R Schrott, SK Murphy - Environmental Epigenetics, 2020 - academic.oup.com
… inheritance of an alteredspermDNAmethylation pattern, we turned to a rat model of THC exposure. We first looked at the sperm of male ratsexposed to 4 mg/kg THC (a dose reflecting …
… suggests that alteredDNAmethylation and chromatin … , THC-induced changes in ratsperm methylation162 overlapped with methylation changes previously reported in the brain of rat …
R Meccariello, A Santoro, S D'Angelo… - International journal of …, 2020 - mdpi.com
… observation, Δ 9 THCexposure-dependent changes in the DNAmethylation of ratsperm [80] … On the other hand, the alteredDNAmethylation of both GPR55 and CB1 encoding genes, …