State trends of cannabis liberalization as a causal driver of increasing testicular cancer rates across the USA

AS Reece, GK Hulse - … Journal of Environmental Research and Public …, 2022 - mdpi.com
… the use of cannabis across many US States has changed rapidly in recent … From seminomas
there is a DNA methylation gradient … of human and rat sperm to a large degree [52,53]. In …

Cannabinoid exposure during pregnancy and its impact on immune function

C Dong, J Chen, A Harrington, KY Vinod… - Cellular and Molecular …, 2019 - Springer
… Synthetic cannabinoids are mind-altering chemicals or … of rat and human endometrial stromal
cells [65, 66] and sperm … The epigenetic regulatory machinery includes DNA methylation, …

Prenatal cannabinoid exposure: emerging evidence of physiological and neuropsychiatric abnormalities

MG Nashed, DB Hardy, SR Laviolette - Frontiers in psychiatry, 2021 - frontiersin.org
… use specifically, direct evidence now exists, in both humans and rats, demonstrating that
Δ9–THC exposure alters DNA methylation in sperm cells (115). These alterations may …

The impact of early life exposure to cannabis: The role of the endocannabinoid system

AA Martínez-Peña, GA Perono, SA Gritis… - International Journal of …, 2021 - mdpi.com
… Chronic exposure to Δ 9 -THC has been shown to alter trophoblast expression of … In a
recent study conducted in rats, gestational Δ 9 -THC exposure significantly reduced birthweight …

Exposure to drugs of abuse induce effects that persist across generations

AM Baratta, RS Rathod, SL Plasil, A Seth… - International review of …, 2021 - Elsevier
… epigenetics while explaining DNA methylation and they said … hereditary impact on the
maturing sperm. Compared to the … , cocaine, nicotine, cannabinoids, and opioids that have been …

Trans-generational Effects of Parental Exposure to Drugs of Abuse on Offspring Memory Functions

J Riyahi, Z Taslimi, F Gelfo, L Petrosini… - … & Biobehavioral Reviews, 2024 - Elsevier
… to produce eggs and sperm. Hence, environmental factors … In particular, during DNA
reproduction, the DNA methylation of … Parental exposure to opioid or cannabinoid agonists can …

[HTML][HTML] DNA methylation, environmental exposures and early embryo development

M Breton-Larrivée, E Elder, S McGraw - Animal reproduction, 2019 - SciELO Brasil
… Paternal alcohol exposure affects sperm cytosine … upon early development in mice and
rats. IX. Late effect of … drugs (eg, cocaine, cannabis) exposure have been linked to lasting …

[HTML][HTML] Transgenerational disease specific epigenetic sperm biomarkers after ancestral exposure to dioxin

MB Maamar, E Nilsson, JLM Thorson, D Beck… - Environmental …, 2021 - Elsevier
… ) to identify potential sperm DNA methylation biomarkers for … F3 generation dioxin lineage
male rats with and without a … had altered DNA methylation in the F3 generation sperm at ap …

Prenatal nicotine exposure leads to epigenetic alterations in peripheral nervous system signaling genes in the testis of the rat

O Dali, JA Muriel-Muriel, A Vargas-Baco… - Epigenetics & …, 2024 - Springer
… that alterations in either DNA methylationalteration of DNA methylation at important germline
reprogramming genes. Pilsner et al. evaluated the influence of cigarette smoking on sperm-…

Maternal high-fat diet impairs leptin signaling and up-regulates type-1 cannabinoid receptor with sex-specific epigenetic changes in the hypothalamus of newborn rats

MM Almeida, CP Dias-Rocha, CF Reis-Gomes… - …, 2019 - Elsevier
… that molecular mechanisms were modified prior to obesity … of Cnr1 gene codes type-1
cannabinoid receptor (CB1)); Ac: … We explored DNA methylation around exon 1 because it is …