The caspase-3/PKCδ/Akt/VEGF-A signaling pathway mediates tumor repopulation during radiotherapy

J Cheng, S He, M Wang, L Zhou, Z Zhang, X Feng… - Clinical cancer …, 2019 - AACR
caspase-3mediated PKCδ cleavage and activation might be involved in tumor repopulation
during radiotherapy. … involvement in radiotherapy-induced tumor cell repopulation suggests …

[HTML][HTML] Caspase-3 knockout attenuates radiation-induced tumor repopulation via impairing the ATM/p53/Cox-2/PGE2 pathway in non-small cell lung cancer

M Zhao, Y Wang, Y Zhao, S He, R Zhao, Y Song… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
tumor cells to cause tumor recurrence. We investigated the function of caspase-3 in NSCLC
repopulation after radiotherapy. … that caspase-3 promotes tumor repopulation in NSCLC cells

[HTML][HTML] Necroptosis regulates tumor repopulation after radiotherapy via RIP1/RIP3/MLKL/JNK/IL8 pathway

Y Wang, M Zhao, S He, Y Luo, Y Zhao, J Cheng… - … & Clinical Cancer …, 2019 - Springer
Tumor cell repopulation after radiotherapy is a major cause for the … Our findings suggest
that activation of cell death-promoting factors (such as caspase 3 cleavage, HMGB1 release and …

Tumor cells suppress radiation-induced immunity by hijacking caspase 9 signaling

C Han, Z Liu, Y Zhang, A Shen, C Dong, A Zhang… - Nature …, 2020 - nature.com
radiation therapy for Casp9 −/− tumors. To further address which T cell population plays the
dominant role in limiting tumor … in tumor-derived type I IFN production and radiation therapy

Paradoxical roles of caspase-3 in regulating cell survival, proliferation, and tumorigenesis

E Eskandari, CJ Eaves - Journal of Cell Biology, 2022 - rupress.org
tumor cell regrowth, caspase-3 stimulated PGE2 release contributes to epithelial–mesenchymal
transition (EMT), anti-cancer … to abrogate tumor repopulation or chemo-resistance. For …

[HTML][HTML] Dying tumor cell-derived exosomal miR-194-5p potentiates survival and repopulation of tumor repopulating cells upon radiotherapy in pancreatic cancer

M Jiang, Y Chen, J Dai, D Gu, Z Mei, F Liu, Q Huang… - Molecular cancer, 2020 - Springer
… processes of tumor repopulation after radiotherapy. In tumor repopulation model in vitro, …
So, we firstly tested the effect of aspirin treatment in tumor cell repopulation model in vitro. …

Dark side of cytotoxic therapy: chemoradiation-induced cell death and tumor repopulation

M Jiang, D Gu, J Dai, Q Huang, L Tian - Trends in cancer, 2020 - cell.com
… These controversies remind us to pay attention to dying cells in cancer … dying tumor cells
and their secretions stimulate repopulation cascades largely through remodeling of the tumor

[HTML][HTML] Apoptotic and predictive factors by Bax, Caspases 3/9, Bcl-2, p53 and Ki-67 in prostate cancer after 12 Gy single-dose

C Pisani, M Ramella, R Boldorini, G Loi, M Billia… - Scientific reports, 2020 - nature.com
… was performed on tumor cells, prostatic intraepithelial neoplasia … of prostate cancer cells to
fraction size radiotherapy 1 . … prostatic tissue in our study population. No significant correlation …

Targets for improving tumor response to radiotherapy

K Mortezaee, W Parwaie, E Motevaseli… - International …, 2019 - Elsevier
… and proliferation of pro-tumor and anti-tumor cells via triggering release of pro-tumor or anti-…
Caspase 3 is a potent stimulator for repopulation of cancer cells [59]. Caspase 3 triggers the …

α-bisabolol enhances radiotherapy-induced apoptosis in endometrial cancer cells by reducing the effect of XIAP on inhibiting caspase-3

D Fang, H Wang, M Li, W Wei - Bioscience Reports, 2019 - portlandpress.com
… -9 and cyclin E during radiotherapy, which further suppressed cancer cells. Furthermore, it
… of killing effect of radiotherapy with α-bisabolol is mediated by XIAP/caspase-3 pathway in …