The recent development of thymol derivative as a promising pharmacological scaffold

CR Sahoo, SK Paidesetty… - Drug Development …, 2021 - Wiley Online Library
perspective, the promising active sites of the scaffold are the … Today, the resistance to
frequently used anti-infective agents … corresponding chalcones were converted into desired target

A comparative review on current and future drug targets against bacteria & malaria

UK Rout, AS Sanket, BS Sisodia… - … Drug Targets, 2020 - ingentaconnect.com
anti-infective agents has shown the way to discover drugs/drug targets with novel molecular
… Few other compounds have been developed based on 4-aminoquinoline scaffold. AQ13 is …

Design, Synthesis, and In Vivo Evaluation of a New Series of Indole-Chalcone Hybrids as Analgesic and Anti-Inflammatory Agents

I Baramaki, MD Altıntop, R Arslan, F Alyu Altınok… - ACS …, 2024 - ACS Publications
… Article Views are the COUNTER-compliant sum of full text … to form pivotal interactions with
biological targets. In this context, … carrying an indole scaffold yielded new chalcones (1–7). The …

Therapeutic potential of naturally occurring benzofuran derivatives and hybrids of benzofurans with other pharmacophores as antibacterial agents

Z Xu, D Xu, W Zhou, X Zhang - Current Topics in Medicinal …, 2022 - ingentaconnect.com
… chemical scaffolds for developing novel antibacterial agents … with a wide range of
pharmacological perspectives [39, 40]. … analogues of chalcone and 1,4-benzodiazepine. Russ. J. …

[HTML][HTML] Development of Orally Active Anti-Inflammatory Agents: In Vivo and In Silico Analysis of Naphthalene-Chalcone Derivatives Based on 2-Acetyl-6-Methoxy …

D Vasudha, A Jagadeesh, SK Konidala, H Yasin… - Chemical Physics …, 2024 - Elsevier
… containing compounds make it an attractive scaffold for design and synthesis of … target
proteins using MVD to locate the interaction between chalcones, and anti-inflammatory target

Challenges and advances in TB drug discovery

G Khare, P Nangpal, AK Tyagi - … Molecular Infection Biology, Pathogenesis …, 2019 - Springer
structure of the compound in question and the drug target, which makes it easier to elucidate
the mechanism of action of the inhibition observed. Besides, the structural … diverse scaffolds

Antioxidant activities of alkyl substituted pyrazine derivatives of chalcones—in vitro and in silico study

V Stepanić, M Matijašić, T Horvat, D Verbanac… - Antioxidants, 2019 - mdpi.com
… modulatory effects on different molecular targets depending on the … anti-infective effects
[6,7,8]. Antiproliferative activity of … The chalcone skeleton is a privileged scaffold in medicinal …

High-throughput screening of natural product and synthetic molecule libraries for antibacterial drug discovery

NJ Ayon - Metabolites, 2023 - mdpi.com
… bioactive molecules and the identification of molecular targets of … on core scaffolds, with
general structural characteristics of … also should be realistic from the infrastructure point of view. …

Synthesis of chalcone derivatives by Claisen-Schmidt condensation and in vitro analyses of their antiprotozoal activities

GB Souza, TAC Santos, APS Silva… - Natural Product …, 2024 - Taylor & Francis
anti-infective agents. So, in the present study, we report on the synthesis and structural
characterisation of chalcone derivatives as drug … that they have different target or mechanism of …

Oxadiazole scaffolds in anti-tuberculosis drug discovery

SS De, MP Khambete, MS Degani - Bioorganic & medicinal chemistry …, 2019 - Elsevier
… explored while the linker was chalcone or hydrazide. The … activity along with their anti-infective
potential. However, … scope to explore potential of oxadiazoles from these perspectives. …