Changes of the coronary arteries and cardiac microvasculature with aging: Implications for translational research and clinical practice
F Piccirillo, M Carpenito, G Verolino, C Chello… - Mechanisms of ageing …, 2019 - Elsevier
Aging results in functional and structural changes in the cardiovascular system, translating
into a progressive increase of mechanical vessel stiffness, due to a combination of changes
in micro-RNA expression patterns, autophagy, arterial calcification, smooth muscle cell
migration and proliferation. The two pivotal mechanisms of aging-related endothelial
dysfunction are oxidative stress and inflammation, even in the absence of clinical disease. A
comprehensive understanding of the aging process is emerging as a primary concern in …
into a progressive increase of mechanical vessel stiffness, due to a combination of changes
in micro-RNA expression patterns, autophagy, arterial calcification, smooth muscle cell
migration and proliferation. The two pivotal mechanisms of aging-related endothelial
dysfunction are oxidative stress and inflammation, even in the absence of clinical disease. A
comprehensive understanding of the aging process is emerging as a primary concern in …
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