… in the disposition of orally administered drugs, nutrients and xenobiotics. In this … organic
anion transporting polypeptide (OATP) transporters have been frequently discussed as clinically …

… transported substrates, OATPs have important roles both in the kinetics of drug disposition
and in drug-drug … that are a substrate for the same OATP are given concurrently (Kindla et al., …

… uptake transporters are found in the solute carrier organic anion (… organic anion transporting
polypeptides (OATP). Accordingly, the SLCO nomenclature stands for the gene, while “OATP…

… such as dicarboxylates and cyclic nucleotides[4], while OATPs transport large hydrophobic
organic anions such as bile acids, thyroid hormones, prostaglandins, testosterone, and …

… Hepatic uptake mediated by organic anion transporting polypeptide (OATP) 1B1 and 1B3
can serve as a major elimination pathway for various anionic drugs and as a site of drug-drug …

… SIGNIFICANCE STATEMENT Presently, there is limited direct clinical evidence supporting
the notion that human liver and gut organic anion transporting polypeptides (OATPs) are …

… Organic anion transporting polypeptides (OATPs) 1B1 and 1B3 facilitate the uptake of drugs
… , and the evaluation of their role in drug disposition is recommended by regulatory agencies …

… and disposition of lipophilic compounds: the importance of degree … The transport mechanism
via OATP transporters is believed … of other anions such as glutathione or bicarbonate [1, 6]. …

… Organic anion transporter polypeptides (OATPs), encoded by the SLCO genes, are one of
the most important SLC subfamilies that contribute to drug and … to the disposition of drugs in …

… organic anion transporting polypeptides (OATPs)—1B1 and—1B3, there is another isoform
of the OATP sub-… on OATP2B1 as it relates to drug disposition and interactions, and provides …