Cryo-EM structures of anti-malarial antibody L9 with circumsporozoite protein reveal trimeric L9 association and complete 27-residue epitope

P Tripathi, MF Bender, H Lei, LDS Pereira, CH Shen… - Structure, 2023 - cell.com
antibody L9 recognizes the Plasmodium falciparum … L9 and PfCSP, we sought to obtain
cryo-EM reconstructions of antibodyfalciparum circumsporozoite protein with a vaccine-elicited

[HTML][HTML] Diverse antibody responses to conserved structural motifs in Plasmodium falciparum circumsporozoite protein

T Pholcharee, D Oyen, JL Torres… - Journal of molecular …, 2020 - Elsevier
… The importance of this conformation is shown in the cryo-EM structure of Fab311 in complex
with rsCSP where type I β-turns and Asn pseudo 3 10 turns repeatedly interchange each …

Protective effects of combining monoclonal antibodies and vaccines against the Plasmodium falciparum circumsporozoite protein

LT Wang, LS Pereira, PK Kiyuka, A Schön… - PLoS …, 2021 - journals.plos.org
… of the Plasmodium falciparum (Pf) circumsporozoite protein (… vaccine that induces polyclonal
antibodies against the repeat … vaccine-induced polyclonal antibodies. These data should …

Structure and mechanism of monoclonal antibody binding to the junctional epitope of Plasmodium falciparum circumsporozoite protein

…, A Bradley, CR King, D Emerling, P Kellam… - PLoS …, 2020 - journals.plos.org
… antigen on Plasmodium falciparum sporozoites, the circumsporozoite protein (PfCSP), has
been an attractive target for vaccine development and most protective antibodies studied to …

Structural basis of Plasmodium vivax inhibition by antibodies binding to the circumsporozoite protein repeats

I Kucharska, L Hossain, D Ivanochko, Q Yang… - Elife, 2022 - elifesciences.org
… Malaria is a global health burden, with Plasmodium falciparum (Pf) and Plasmodium vivax
(… Circumsporozoite protein (CSP) is the most abundant protein on the surface of Plasmodium

A potent anti-malarial human monoclonal antibody targets circumsporozoite protein minor repeats and neutralizes sporozoites in the liver

LT Wang, LS Pereira, Y Flores-Garcia, J O'Connor… - Immunity, 2020 - cell.com
… monoclonal antibodies (mAbs) targeting the Plasmodium falciparum circumsporozoite
protein (… , and demonstrates that the liver is an important site for antibodies to prevent malaria. …

Biophysical characterization of the Plasmodium falciparum circumsporozoite protein's N‐terminal domain

…, R Amino, H De Winter, AN Volkov, P Tompa… - Protein …, 2024 - Wiley Online Library
… of the Plasmodium falciparum circumsporozoite protein: Effects on cytotoxic and antibody
Role of cysteines in Plasmodium falciparum circumsporozoite protein: Interactions with …

Structural basis of epitope selectivity and potent protection from malaria by PfCSP antibody L9

GM Martin, ML Fernández-Quintero, WH Lee… - Nature …, 2023 - nature.com
antibody responses against the circumsporozoite protein of the malaria parasite, Plasmodium
falciparum (… , we solved a cryo-EM structure of the highly potent anti-PfCSP antibody L9 in …

High-density binding to Plasmodium falciparum circumsporozoite protein repeats by inhibitory antibody elicited in mouse with human immunoglobulin repertoire

…, GD Tomaras, EA Levashina, P Kellam… - PLoS …, 2022 - journals.plos.org
Antibodies targeting the human malaria parasite Plasmodium falciparum circumsporozoite
protein (… most potent anti-infective antibodies against malaria bind to these repeats. Multiple …

How to induce protective humoral immunity against Plasmodium falciparum circumsporozoite protein

I Wahl, H Wardemann - Journal of experimental medicine, 2022 - rupress.org
… responses against sporozoite surface proteins of the human parasite Plasmodium falciparum
(Pf) … The most promising antibody target is circumsporozoite protein (CSP). Although PfCSP …