A systematic review and meta-analysis of environmental, lifestyle, and health factors associated with DNA methylation age

J Ryan, J Wrigglesworth, J Loong… - The Journals of …, 2020 - academic.oup.com
… ’s chronological age and can predict their risk of age-related disease and mortality. This study
… In conclusion, BMI was positively associated with biological aging measured using DNAm, …

The epigenetic clock as a predictor of disease and mortality risk: a systematic review and meta-analysis

PD Fransquet, J Wrigglesworth, RL Woods, ME Ernst… - Clinical …, 2019 - Springer
… a higher biological age relative to chronological age is a predictor of time-to-death, cancer-…
], and two adjusted for sex using an interaction effect with biological age [11, 78]. Some other …

DNA methylation age as a biomarker for cancer

CHE Lau, O Robinson - International Journal of Cancer, 2021 - Wiley Online Library
… the most widely used biological age markers in cancer … methylation-based estimators of
plasma proteins, which include … meta-analysis examining existing literature of epigenetic age

[HTML][HTML] DNA methylation GrimAge strongly predicts lifespan and healthspan

AT Lu, A Quach, JG Wilson, AP Reiner, A Aviv… - Aging (albany …, 2019 - ncbi.nlm.nih.gov
… Toward this end, we regressed DNAm GrimAge on chronological age using a linear … found
to be weakly predictive of mortality and cardiovascular disease. Our meta-analysis reveals a …

DNA methylation-based age clocks: From age prediction to age reversion

R Noroozi, S Ghafouri-Fard, A Pisarek… - Ageing Research …, 2021 - Elsevier
age prediction clocks which are methylation-based models for estimating various aspects of
aging including chronological age, biological age… all-cause mortality prediction. The lifestyle …

Biological aging measures based on blood DNA methylation and risk of cancer: a prospective study

PA Dugué, JK Bassett, EM Wong, JHE Joo… - JNCI cancer …, 2021 - academic.oup.com
… The methylation-based measures PhenoAge and GrimAge … between biological aging and
cancer and be useful to predict … of DNA methylation with, for PhenoAge, age, mortality, and …

Methylation-based biological age and breast cancer risk

JK Kresovich, Z Xu, KM O'Brien… - JNCI: Journal of the …, 2019 - academic.oup.com
… the most informative set to predict chronological age (20,21). … on the combination of
chronological age and selected blood … was designed as a predictor of age-associated mortality. …

DNA methylation clocks and their predictive capacity for aging phenotypes and healthspan

T Bergsma, E Rogaeva - Neuroscience insights, 2020 - journals.sagepub.com
biological aging and extend healthspan. A reliable measure of biological age could be a factor
in predicting … with longevity and mortality giving the best representation of biological age. …

DNA methylation-based predictors of health: applications and statistical considerations

PD Yousefi, M Suderman, R Langdon… - Nature Reviews …, 2022 - nature.com
biological age, and that discrepancies between clock age and … Indeed, the authors show that
associations with mortalitymeasurements had been used to perform variable prediction. a | …

[HTML][HTML] Chronological age prediction: developmental evaluation of DNA methylation-based machine learning models

H Fan, Q Xie, Z Zhang, J Wang, X Chen… - … in Bioengineering and …, 2022 - frontiersin.org
… estimator, epigenetic clock can not only accurately predict age, mortality, or morbidity but …
of nine DNAm biomarkers was collected by meta-analysis with a number of 7,084 individuals; 2…