Reversal of age-related neuronal atrophy by α5-GABAA receptor positive allosteric modulation

TD Prevot, A Sumitomo, T Tomoda, DE Knutson… - Cerebral …, 2021 - academic.oup.com
… and spine numbers of cortical neurons in vitro. Using old mice… accompanied by increased
prevalence of cognitive decline … we hypothesized that facilitating the action of GABA at the α 5 -…

GABA levels in ventral visual cortex decline with age and are associated with neural distinctiveness

JD Chamberlain, H Gagnon, P Lalwani… - Neurobiology of …, 2021 - Elsevier
… in neural distinctiveness can account for a number of … neurons in young monkeys respond
less selectively, like the … We also found age-related neural dedifferentiation in older compared …

[HTML][HTML] GABAergic dysfunction, neural network hyperactivity and memory impairments in human aging and Alzheimer's disease

J Jiménez-Balado, TS Eich - Seminars in cell & developmental biology, 2021 - Elsevier
… of cognitive functions—usually accompanied or preceded by a deterioration of emotional …
GABA in age-related cognitive decline. Several previous articles have thoroughly reviewed …

Neural distinctiveness declines with age in auditory cortex and is associated with auditory GABA levels

P Lalwani, H Gagnon, K Cassady, M Simmonite… - Neuroimage, 2019 - Elsevier
neural factor that may play a role is an age-related decline in … of single neurons and that
age-related declines in GABA levels … partially due to anatomical changes that accompany aging. …

Morphological and neurochemical changes in GABAergic neurons of the aging human inferior colliculus

I Pal, CRB Paltati, C Kaur, S Saini, P Kumar, TG Jacob… - Hearing Research, 2019 - Elsevier
… profile is deleterious to neuronal health, therefore several … investigate the number of neurons
and expression of GABA and … significant age-related decline in the total number of neurons

Aging and central auditory disinhibition: is it a reflection of homeostatic downregulation or metabolic vulnerability?

BA Ibrahim, DA Llano - Brain Sciences, 2019 - mdpi.com
… activity; diminished hemispheric lateralization of neural responses; … GABA receptor expression)
[61], suggesting that lowered … Such high levels of age-related markers of oxidative stress …

Age-related changes in the auditory brainstem and inferior colliculus

J Syka - Aging and Hearing: Causes and Consequences, 2020 - Springer
… In summary, aging is accompanied in the CN by decreases in … of a significant age-related
neuronal loss. Thus, aging is not … , the number of GABA-immunoreactive neurons was reduced

Neural mechanisms underlying age-related changes in attentional selectivity.

BL Kennedy, M Mather - 2019 - psycnet.apa.org
Decreased proportion of GABA neurons accompanies age-related degradation of neuronal
function in cat striate cortex. Brain Research Bulletin, 75, 119–125. http://dx.doi.org/10.1016/ j…

Age-dependent changes in synaptic NMDA receptor composition in adult human cortical neurons

CM Pegasiou, A Zolnourian, D Gomez-Nicola… - Cerebral …, 2020 - academic.oup.com
… and proteomic degradation. We show an age-dependent … mechanism in the age-related
decline in cognitive abilities and … individuals having a higher proportion of synaptic GluN2B-…

Dynamic recovery: GABA agonism restores neural variability in older, poorer performing adults

P Lalwani, DD Garrett, TA Polk - Journal of Neuroscience, 2021 - Soc Neuroscience
… variability, we examined whether reduced brain signal … then decomposed using singular
value decomposition (SVD). This … in brain regions showing age-related reductions in SD BOLD , …