… a marker of impairment rather than disability. Between an … confirmed EDSS progression
definitions have been shown to … -rater reliability on the MSFC show excellent results. These …

… : high reliability; coverage of cognition, which is not adequately captured by other … events
defined by the performance tests were weakly associated with or independent of those defined …

… outcomes. In this perspective review, we describe the importance of and methods for using
PRO in MS by defining … seems to underline that disabled pwMS cannot have a “good” QoL; a …

… -term outcomes and prolong the time to milestone disability … Multiple sclerosis relapses
were defined as the appearance … Confirmed multiple sclerosis relapses were defined as those …

… the worsening of multiple sclerosis (MS)-related disability and (2) … Results suggest that the
SDMT has good construct validity … The definition of disability worsening for the SDMT that most …

… who reached the disability outcome according to whether … of patients reaching the disability
outcome. Secondly, the log-rank … groups defined by the attainment of the disability outcome in …

… reported inconsistent results when examining the association between disability, primarily
… We found invisible symptoms, defined as symptoms that affect the patient greatly but are not …

… there is good correlation with long-term clinical outcomes 57. … with clinical outcomes, most
notably cognitive impairment 58. … measures for relapsing disease are relatively easy to define; …

… reliability. We therefore sought to investigate other reliable and valid measures of impairment…
the studies vary by outcome investigated, sample size, and definition of the exposure; and …

… defined as a patient's perception of an abnormal physical, emotional or cognitive state, and
these in turn may affect disability, … upon symptoms, disability and QoL as outcomes for DMT …