Uncarboxylated matrix Gla-protein: a biomarker of vitamin K status and cardiovascular risk

T Jespersen, LT Møllehave, BH Thuesen, T Skaaby… - Clinical …, 2020 - Elsevier
Dephosphorylated uncarboxylated matrix Gla-protein (dp-ucMGP) is a biomarker of functional
vitamin K status. … (Gla)-containing proteins such as Matrix Gla Protein (MGP). MGP is a …

Plasma Dephosphorylated-Uncarboxylated Matrix Gla-Protein in Systemic Sclerosis Patients: Biomarker Potential for Vascular Calcification and Inflammation

J Potjewijd, R Tobal, KA Boomars, VVPM van Empel… - Diagnostics, 2023 - mdpi.com
… mortality predictor over … Matrix Gla-protein (MGP) is a vitamin K-dependent protein involved
in the inhibition of both intimal and medial vascular calcification. It is a small secretory protein

Association of the inactive circulating matrix Gla protein with vitamin K intake, calcification, mortality, and cardiovascular disease: a review

S Roumeliotis, E Dounousi, T Eleftheriadis… - International journal of …, 2019 - mdpi.com
… “Matrix Gla protein,” “MGP polymorphism,” “inactive MGP,” “dephosphorylated MGP,” “uncarboxylated
MGP,” and “vitamin K … and independent predictor of plasma dpucMGP levels [61]. …

Vitamin K–dependent matrix gla protein as multifaceted protector of vascular and tissue integrity

FF Wei, S Trenson, P Verhamme, C Vermeer… - …, 2019 - Am Heart Assoc
… secretory protein (11 kD), which is named MGP (matrix Gla protein), because it contains 5
γ-carboxyglutamate (Gla) … Moreover, plasma dp-ucMGP is a predictor of mortality and adverse …

Vascular calcification in chronic kidney disease: the role of vitamin K-dependent matrix Gla protein

S Roumeliotis, E Dounousi, M Salmas… - Frontiers in …, 2020 - frontiersin.org
… that vitamin K deficiency was a strong, independent predictor of CVD, mortality and incidence
of CKD (55, 56). Chen et al., conducted a meta-analysis of 21 studies including 222,592 …

Relationship of matrix Gla protein and vitamin K with vascular calcification in hemodialysis patients

S Mizuiri, Y Nishizawa, K Yamashita, K Ono, T Naito… - Renal …, 2019 - Taylor & Francis
… not a significant predictor for CACS or the presence of CVD in MHD patients in our study. …
(eg total uncarboxylated MGP, dephosphorylated-uncarboxylated MGP, and dephosphorylated-…

Plasma dephosphorylated-uncarboxylated Matrix Gla-Protein (dp-ucMGP): reference intervals in Caucasian adults and diabetic kidney disease biomarker potential

TP Griffin, MN Islam, D Wall, J Ferguson, DG Griffin… - Scientific reports, 2019 - nature.com
… , heart, and kidney express high levels of mRNA for the vitamin K-dependent matrix Gla
Desphospho-uncarboxylated matrix Gla protein is a novel circulating biomarker predicting

Circulating levels of dephosphorylated-uncarboxylated matrix gla protein in patients with acute coronary syndrome

A Bilalic, T Ticinovic Kurir, M Kumric, JA Borovac… - Molecules, 2021 - mdpi.com
Matrix GLA protein (MGP), a vitamin K dependent protein, on … increased levels of the
dephosphorylated-uncarboxylated … as a significant predictor of high dp-ucMGP levels in our study. …

[HTML][HTML] Vitamin K2 Dependent Matrix Gla Protein Relating to Abdominal Aortic Aneurysm and Overall Mortality: A Combined Case Control and Cohort Study

JSS Kristensen, L Melholt, KL Kristensen… - European Journal of …, 2021 - Elsevier
… the mechanism is unknown and highest level evidence from randomised trials is missing. …
a predictive tool regarding long term mortality risk. Furthermore, it is speculated that vitamin K 2 …

Higher levels of circulating desphospho-uncarboxylated matrix Gla protein over time are associated with worse survival: the prospective Maastricht Intensive Care …

MMG Mulder, J Schellens, JWEM Sels… - Journal of Intensive …, 2023 - Springer
… hepatic vitamin K-status, measured by dephosphorylated uncarboxylated matrix Gla protein
(dp-ucMGP), maintains vascular health, with high levels reflecting poor vitamin K status. The …