… differentiation by the expression pattern of cluster of … that resistance to steroids is mediated
through altered signaling … phosphorylates retinoblastoma tumor suppressor protein (Rb), …

… role is played by NOTCH1 and CDKN2A, as they are altered in … Resistance Profiling (DSRP)
studies, we confirmed BCL2 … of T-cell differentiation, block of the myeloid differentiation, and …

… -E2F along with Cyclin-Cdk complexes typically involved in development and differentiation
… These chromatinremodeling complexes use the energy derived from ATP hydrolysis to alter …

… As a consequence, leukemia cells become more resistant to … avoid differentiation, also change
the phenotype and function … cell compartment was most significantly changed in BCP-ALL …

… drugs and develop drug resistance. Hematopoietic stem cells (… very important role in T and
B lymphocyte differentiation and … altered function of the encoded fusion protein impairs normal …

… role in regulating development and differentiation via diverse cellular processes, such as
differentiation… leukemia: RAS mutations and prednisolone resistance. Haematologica 2015;100:…

… patients with acute lymphoblastic leukemia (ALL). Development of chemo-resistance is …
understanding the molecular basis underlying resistance is imperative for developing innovative …

… Relapse is a result of the proliferation of the most resistant … , which are capable of differentiating
into T cells and marrow cells… levels of MDM2 and RB are regulated by the CDKN2A gene, …

… Nuclear c-Raf interacted with RB protein and specifically with … with the effect of ATRA modified
by roscovitine. Segregation by … ATRA resistant AML susceptible to differentiation therapy. …

… apoptotic members of the BCL-2 protein family, such as Bcl-2… the induced myeloid leukemia
cell differentiation protein (Mcl-1)… resistant Reh cells, levels of the proteins were not changed […