Direct septum-hippocampus cholinergic circuit attenuates seizure through driving somatostatin inhibition
Background Previous studies indicated the involvement of cholinergic neurons in seizure;
however, the specific role of the medial septum (MS)-hippocampus cholinergic circuit in
temporal lobe epilepsy (TLE) has not yet been completely elucidated. Methods In the current
study, we used magnetic resonance imaging and diffusion tensor imaging to characterize
the pathological change of the MS-hippocampus circuit in 42 patients with TLE compared
with 22 healthy volunteers. Using optogenetics and chemogenetics, combined with in vivo or …
however, the specific role of the medial septum (MS)-hippocampus cholinergic circuit in
temporal lobe epilepsy (TLE) has not yet been completely elucidated. Methods In the current
study, we used magnetic resonance imaging and diffusion tensor imaging to characterize
the pathological change of the MS-hippocampus circuit in 42 patients with TLE compared
with 22 healthy volunteers. Using optogenetics and chemogenetics, combined with in vivo or …
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