… over-represented in re-replicated DNA shared common epigenetic properties. We found that
… Similar results were obtained when we used a different strategy to map re-replicating origins…

… of 43 epigenetic marks present at replication origins in … classes of replication origins that are
characterized by different … cell divisions, replication origin sites and density are different from …

… that accompanies excess replication origin activation can … modulate replication origin
dormancy, prevent excess origin … genome duplication process into two distinct phases, origin …

… core origins are more ubiquitously active in different cell types, 72% of core … feature of
replication origins in metazoan cells. We also acknowledge that a combination of select epigenetic …

… since several chromatin marks, some of which are directly or indirectly linked to SIRT1 activity,
were found to associate with different subsets of origins (ie early versus late origins) (21). …

… able to identify 5 distinct features in the landscape of DNA replication across the genome (…
Overall, we conclude that the SNS method is primarily able to detect early replicating origins, …

… and differences in replication origin organization and … Specific DNA elements and epigenetic
features involved in … Importantly, origin properties vary not only between different origins in …

… 5 distinct features in the landscape of DNA replication across … is primarily able to detect
early replicating origins, while OK-… differentiated by their distinct epigenetic features. TTRs lack …

… To test their propensity to form a G4-structure, we selected origins in different chromatin
domains… Transcription and epigenetic landscape in the different origin classes. a Venn diagrams …

… replication origins between SNS-seq samples from Ezh2 +/+ and Ezh2 Δ/Δ cells using DiffBind,
a computational tool that identifies statistically different … to ask whether epigenetic marks …