… histone epigenome of Plasmodium vivax salivary-gland sporozoites point to tight regulatory control and mechanisms for liver-stage differentiation in relapsing malaria

I Muller, AR Jex, SHI Kappe, SA Mikolajczak… - International journal for …, 2019 - Elsevier
… We identified differential transcription between the sporozoite … Numbers in each box show
mean transcription in TPM. (For … We suggest differentiation programming at different points in …

Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites

SE Lindner, KE Swearingen, MJ Shears… - Nature …, 2019 - nature.com
… and differential expression analyses of sporozoites from rodent-… UIS Proteins for the two
distinct malaria parasite species. … as compared to de novo transcription, we hypothesize that …

Transcriptional heterogeneity and tightly regulated changes in gene expression during Plasmodium berghei sporozoite development

HN Bogale, TV Pascini, S Kanatani… - Proceedings of the …, 2021 - National Acad Sciences
… Our results reveal a succession of tightly regulated changes … of sporozoites collected at
different sites clearly indicated that … ), we excluded these parasites from the differential analysis …

Transcriptome profiling reveals functional variation in Plasmodium falciparum parasites from controlled human malaria infection studies

R Hoo, E Bruske, S Dimonte, L Zhu, B Mordmüller… - …, 2019 - thelancet.com
… a unique transcriptional signature of a single strain malariaTranscriptional changes between
sporozoite route of … Differential gene expression analysis for each gene was calculated as …

Single-cell RNA sequencing of Plasmodium vivax sporozoites reveals stage- and species-specific transcriptomic signatures

AA Ruberto, C Bourke, A Vantaux… - PLOS Neglected …, 2022 - journals.plos.org
… , we found three distinct populations of sporozoites (Fig 2B). … the transcription profiles of
genes implicated in sporozoitesporozoite data (Figs 6A and S7E) and performed differential

Single-cell transcription analysis of Plasmodium vivax blood-stage parasites identifies stage- and species-specific profiles of expression

JM Sa, MV Cannon, RL Caleon, TE Wellems… - PLoS …, 2020 - journals.plos.org
… , Plasmodium parasites in the form of sporozoites move from … revealed distinct populations
of blood-stage parasites. Two of … Such differential transcription is consistent with various roles …

Whole-blood transcriptomic signatures induced during immunization by chloroquine prophylaxis and Plasmodium falciparum sporozoites

TM Tran, EM Bijker, MC Haks, THM Ottenhoff… - Scientific Reports, 2019 - nature.com
… This approach, termed chemoprophylaxis with sporozoites (CPS), provides a unique
measure of transcriptional activity, we refrain from concluding that the differential expression of any …

Plasmodium vivax transcriptomes reveal stage-specific chloroquine response and differential regulation of male and female gametocytes

A Kim, J Popovici, D Menard, D Serre - Nature communications, 2019 - nature.com
… Thus, Pvs47, Pvs48/45, Hap2, the gamete egress and sporozoite traversal protein, s16, and
… vivax 21 , we also tested whether the transcription of different isoforms was associated with …

Alternative splicing is required for stage differentiation in malaria parasites

LM Yeoh, CD Goodman, V Mollard, E McHugh, VV Lee… - Genome biology, 2019 - Springer
… KO parasites to analyze the changes in different categories of … We demonstrate that
post-transcriptional regulation by … Oocyst and sporozoite numbers were quantified by analysis …

Preparing for Transmission: Gene Regulation in Plasmodium Sporozoites

S Briquet, C Marinach, O Silvie… - … in Cellular and Infection …, 2021 - frontiersin.org
… multiple layers of transcriptional and post-transcriptional regulatory … Malaria parasites also
express distinct rRNA genes at … analysis reveals reduced transcriptional activity in the malaria